2026-10-14T08:33:41Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34017434 2026-09-28T17:51:11Z category_1 category_12 category_13 category_14 category_46 category_734 category_61 category_64 portal_5 item_type_3 month_year_09_2026

<p>Differentially expressed genes (DEGs) across genotypes and dietary conditions in zebrafish larvae.</p> Siyao Wang (1468693) Laura Childers (25132808) Fernando Martinez III (25132811) Michel Bagnat (3906664) Jieun Park (2560948) Biophysics Cell Biology Genetics Molecular Biology Immunology Biological Sciences not elsewhere classified Developmental Biology Cancer using transcriptome profiling uncover mechanisms underlying genetic analyses indicate wide transcriptional changes impairs lre differentiation low protein diet mutants exhibit upregulation homozygous mutants surviving div >< p poor survival due multiple generations resulted allele upon inbreeding zebrafish </ p dietary protein absorption transcriptional regulation lre endocytic dietary proteins protein malnutrition protein absorption pllp </ zebrafish loss survival rates study illustrates stable improvements specialized population rich enterocytes recurrent adaptation pllp ), organismal survival newly generated neonatal mammals natural selection mutant allele may contribute marked reduction intestinal function intestinal cells independently generated increased exposure immune genes environmental antigens enhanced survival absorptive activity <p>Lists of DEGs identified via pairwise differential expression analysis using DESeq2, factoring in both diet and genotype as covariates. DEGs were strictly defined by a False Discovery Rate (FDR; padj) < 0.05 and an absolute Log2fold change (|LFC|) > 1. The spreadsheet is organized into nine distinct tabs corresponding to each pairwise comparison: Tab 1 (pd1116 HP vs LP): DEGs reflecting the dietary effect within the pd1116-/- mutant genotype. Tab 2 (pd1245 HP vs LP): DEGs reflecting the dietary effect within the pd1245-/- mutant genotype. Tab 3 (EK HP vs LP): DEGs reflecting the dietary effect within the wild-type EK genotype. Tab 4 (HP 1116 vs EK): DEGs showing genotype differences between pd1116-/- mutants and EK wild-type under High Protein conditions. Tab 5 (HP 1245 vs 1116): DEGs showing genotype differences between pd1245-/- and pd1116-/- mutants under High Protein conditions. Tab 6 (HP 1245 vs EK): DEGs showing genotype differences between pd1245-/- mutants and EK wild-type under High Protein conditions. Tab 7 (LP 1116 vs EK): DEGs showing genotype differences between pd1116-/- mutants and EK wild-type under Low Protein conditions. Tab 8 (LP 1245 vs 1116): DEGs showing genotype differences between pd1245-/- and pd1116-/- mutants under Low Protein conditions. Tab 9 (LP 1245 vs EK): DEGs showing genotype differences between pd1245-/- mutants and EK wild-type under Low Protein conditions. Each tab contains gene symbols, base mean expressions, Log2 fold changes, standard errors, test statistics, p-values, and adjusted p-values.</p> <p>(XLSX)</p> 2026-09-28T18:02:07Z Dataset Dataset 10.1371/journal.pgen.1012071.s001 https://figshare.com/articles/dataset/_p_Differentially_expressed_genes_DEGs_across_genotypes_and_dietary_conditions_in_zebrafish_larvae_p_/34017434 CC BY 4.0