2026-10-13T16:05:26Z
https://api.figshare.com/v2/oai
oai:figshare.com:article/34016499
2026-09-28T17:34:46Z
category_7
category_21
category_46
category_64
category_106
category_132
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portal_5
item_type_3
month_year_09_2026
<p>Characteristics of participants (n = 81).</p>
Aniek M. Kolen (10302173)
Leonie A. Krops (3622208)
Harriët Jager-Wittenaar (8038742)
Martijn L. Dijkstra (20424908)
B. Paul J. A. Keller (25132671)
Jacques Oskam (25132674)
Bastiaan P. Vierhout (25132677)
Jean-Paul P. M. de Vries (3284052)
Laurens van Walraven (25132680)
Wim P. Krijnen (2847782)
Rienk Dekker (393389)
Jan H. B. Geertzen (8655027)
Medicine
Biotechnology
Immunology
Cancer
Science Policy
Infectious Diseases
Virology
e ., age
charlson comorbidity index
body mass index
adverse clinical outcomes
2340 ], 1920
2199 ], 2053
114 ], 84
100 ], 88
lower physical activity
xlink "> people
xlink "> median
9 months post
physical activity level
alarmingly prevalent post
dysvascular major lla
improve nutritional status
physical activity
xlink ">
alarmingly prevalent
2240 ],
101 ],
nutritional status
smoking status
pain level
education level
nutritional intervention
nutritional intake
6 months
triceps skinfold
six hospitals
protein intake
hour recall
high risk
grip strength
every hour
energy intake
care facility
81 ).
5 weeks
12 days
<div>
<p>Introduction</p><p>People who have undergone dysvascular major lower limb amputation (LLA) are at high risk for adverse clinical outcomes, including undernutrition. However, prevalence of undernutrition in this population is unknown. Therefore, the aim of this study was to determine the nutritional intake and prevalence of undernutrition post-LLA, and to identify determinants of undernutrition.</p>
<p>Methods</p><p>In this prospective longitudinal observational study, adults who underwent a dysvascular major LLA were included in six hospitals (n = 81). At several measurement occasions following amputation (<12 days, 5 weeks, 6 months, 9 months), participants’ nutritional intake (24-hour recall) and nutritional status (Patient-Generated Subjective Global Assessment, body mass index, grip strength, mid upper arm circumference, and triceps skinfold) were determined. Furthermore, the Dutch Healthy Diet index was determined. Potential determinants of undernutrition, i.e., age, sex, Charlson comorbidity index, LLA level, uni/bilateral LLA, education level, living situation, smoking status, pain level, and physical activity level, were assessed using mixed effect models.</p>
<p>Results</p><p>Median [Q1; Q3] energy intake was 1647 [1178; 2199], 2053 [1516; 2340], 1920 [1263; 2240], and 1797 [1343; 2211] kcal/day (p = 0.002), and protein intake was 76 [59; 100], 88 [68; 114], 84 [64; 101], and 75 [57; 97] grams/day (p = 0.017) at <12 days, 5 weeks, 6 months, and 9 months post-LLA, respectively. Prevalence of undernutrition was 83%, 56%, 28%, and 24%. Determinants of undernutrition were: living in a care facility (OR=6.2, p < 0.001) and lower physical activity (OR=0.96 for every hour of physical activity/week, p = 0.006). Need for nutritional intervention was present in 100%, 82%, 67% and 54% of participants at <12 days, 5 weeks, 6 months, and 9 months post-LLA.</p>
<p>Conclusion</p><p>Inadequate nutritional intake and undernutrition are alarmingly prevalent post-LLA. Living in a care facility and lower physical activity are determinants of undernutrition. Interventions to improve nutritional status, to potentially optimize clinical outcomes in the dysvascular major LLA population are highly needed.</p></div>
2026-09-28T17:34:38Z
Dataset
Dataset
10.1371/journal.pone.0342726.t001
https://figshare.com/articles/dataset/_p_Characteristics_of_participants_n_81_p_/34016499
CC BY 4.0