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oai:figshare.com:article/34016001 2026-09-28T17:27:16Z category_7 category_21 category_734 category_811 category_62 category_132 portal_5 item_type_3 month_year_09_2026

<p>Population mean and predicted study-specific coefficients from the fitted random effects model using creatinine (model n = 13,391, Panel A) or cystatin C (model n = 7,496, Panel B). Studies 1 through 13 denote studies of non-CKD populations and studies 14 through 26 studies of CKD populations. Lower slopes refer to slopes prior to a given knot point, while higher slopes refer to slopes after the knot point. Cells marked with “–” indicate that the coefficient could not be estimated for that study. Studies 3, 4, and 26 did not report cystatin C measurements.</p> Nora Fino (13410079) Ben Haaland (15178015) Lesley A. Inker (20370754) Andrew Levey (25132644) Josef Coresh (93441) Ogechi M. Adingwupu (20370757) Tom Greene (71869) Medicine Biotechnology Biological Sciences not elsewhere classified Mathematical Sciences not elsewhere classified Marine Biology Infectious Diseases routine clinical practice results largely corroborate random effect models random &# 8208 glomerular filtration rate combined data used broadly available solution 20 &# 8211 despite measureable study multiple research studies epi apparach remains 26 studies ). single study leads xlink "> overall study prediction error combine serum creatinine patient level errors sex </ p original pooled ckd egfr within studies xlink "> single dataset serum creatinine level error study variation within ckd measurement error level variability level heterogeneity typically created substantial overfitting predictor variables predictable variation population variation population type pooling datasets pooled datasets pooled cki kidney function investigate implications four components cystatin c current form <p>Population mean and predicted study-specific coefficients from the fitted random effects model using creatinine (model n = 13,391, Panel A) or cystatin C (model n = 7,496, Panel B). Studies 1 through 13 denote studies of non-CKD populations and studies 14 through 26 studies of CKD populations. Lower slopes refer to slopes prior to a given knot point, while higher slopes refer to slopes after the knot point. Cells marked with “–” indicate that the coefficient could not be estimated for that study. Studies 3, 4, and 26 did not report cystatin C measurements.</p> 2026-09-28T17:27:03Z Dataset Dataset 10.1371/journal.pone.0357209.t001 https://figshare.com/articles/dataset/_p_Population_mean_and_predicted_study-specific_coefficients_from_the_fitted_random_effects_model_using_creatinine_model_n_13_391_Panel_A_or_cystatin_C_model_n_7_496_Panel_B_Studies_1_through_13_denote_studies_of_non-CKD_populations_and_stu/34016001 CC BY 4.0