2026-10-11T16:29:03Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34015819 2026-09-28T17:25:33Z category_7 category_21 category_64 category_106 category_122 portal_5 item_type_3 month_year_09_2026

<p>Study eligibility criteria.</p> Amanda J. Gupta (12227680) Patricia Turimumahoro (4574023) Fulera Salami (25132564) Ayden Brennan (25132567) David Jacoby (8027144) Sheeba Ibidunni (25132570) Lori Rosman (4633909) Jonathan E. Golub (7866302) David W. Dowdy (8964830) Medicine Biotechnology Cancer Science Policy Mental Health scoping review aimed rarely evaluates interventions prevalent among people organized using reach none evaluated accuracy negatively affects diagnosis facilitators included task demonstrated modest improvements incorporating longitudinal designs 15 %) using xlink "> depression fewer cohort studies evaluate methodologies used methodological approaches used depression measurement tools reported outcomes related depression among pwtb related outcomes methodological approaches studies reported 17 %) clinical outcomes treatment approaches integrated approaches screening tools studying depression treatment adherence systematically mapped study characteristics sectional designs scr guidelines routine workflows relies heavily nine databases identify gaps geographically clustered geographic coverage full texts expanding population diagnostic tool diagnostic interview diagnostic evaluation developing sustainable depressive symptoms clinical criteria 65 %), 4 %). 28 studies <div><p>Depression is prevalent among people with tuberculosis (PWTB) and negatively affects diagnosis, treatment adherence, and clinical outcomes. However, the methodological approaches used to study depression among PWTB have not been systematically mapped. This scoping review aimed to evaluate methodologies used to study depression among PWTB and identify gaps in methodological approaches. We conducted a systematic scoping review following PRISMA-ScR guidelines. Nine databases were searched without date restrictions. Two reviewers independently screened titles, abstracts, and full texts. Inclusion criteria included primary, peer-reviewed, research studies that examined depression among PWTB, and reported outcomes related to TB and depression. Data were extracted on study characteristics, TB population, depression measurement tools, treatment approaches, and implementation considerations. Findings were organized using Reach, Effectiveness, Adoption, Implementation, Maintenance (RE-AIM) framework. A total of 184 studies met inclusion criteria. Research was dominated by cross-sectional designs (65%), with fewer cohort studies (17%) and only eight randomized controlled trials (RCTs, 4%). The RCTs primarily evaluated psychological interventions that demonstrated modest improvements in depressive symptoms or TB-related outcomes. Depression was overwhelmingly assessed using screening tools with only 28 studies (15%) using a diagnostic interview or clinical criteria. None evaluated accuracy of any screening or diagnostic tool. Studies were geographically clustered, with more than one-third conducted in India or China. Implementation barriers to integrated TB and depression care included workforce shortages and stigma; facilitators included task-shifting and embedding screening into routine workflows. No studies reported on maintenance or long-term sustainability of depression care within TB programs. Existing research on depression among PWTB is largely cross-sectional, relies heavily on screening tools, and rarely evaluates interventions or their sustainability. Expanding population and geographic coverage, incorporating longitudinal designs and diagnostic evaluation, and strengthening implementation and maintenance research are critical for developing sustainable, integrated approaches to depression care within TB services.</p></div> 2026-09-28T17:25:22Z Dataset Dataset 10.1371/journal.pgph.0007388.t001 https://figshare.com/articles/dataset/_p_Study_eligibility_criteria_p_/34015819 CC BY 4.0