2026-10-14T09:30:13Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34015083 2026-09-28T15:19:23Z category_374 portal_316 item_type_3 month_year_09_2026

Table 1_Association between dietary branched-chain amino acid intake and anaemia risk in children and adolescents: a matched case-control study.docx Xuan Liu (49954) Shuyi Wu (1534597) Yulin Jiang (352354) Changqing Liu (735150) Yiya Liu (20733332) Meina Tian (2221975) Qianrang Zhu (9324626) Qing Yue (525742) Zhenchuang Tang (23947119) Lianlong Yu (15263075) Clinical and Sports Nutrition anaemia branched-chain amino acids case-control study children and adolescents nutritional epidemiology propensity score matching <p>Anaemia in children and adolescents is multifactorial, and evidence on dietary amino-acid intake in relation to anaemia remains limited. This study examined the association between dietary branched-chain amino acid (BCAA) intake and haemoglobin (Hb)-defined anaemia among Chinese children and adolescents using data from the 2016–2019 China Children and Lactating Women Nutrition and Health Survey. Among 11,134 eligible participants aged 6–17 years, quantile g-computation and the Boruta algorithm were first used to screen 20 dietary amino acids. A 1:4 propensity score-matched sample was then constructed, including 455 participants with anaemia and 1,819 with normal Hb levels. Dietary BCAA intake and its components, isoleucine (Ile), leucine (Leu) and valine (Val), were energy-adjusted using the residual method. Machine learning methods were used exploratorily for feature ranking, and conditional logistic regression was used to estimate odds ratios (ORs). After matching, total dietary protein intake was comparable between groups, whereas intakes of total BCAA, Ile, Leu, and Val were significantly lower in the anaemia group. In fully adjusted models, higher intakes of total BCAA, Ile, Leu, and Val were associated with lower odds of Hb-defined anaemia, with ORs of 0.95 (95% CI: 0.92–0.99), 0.82 (95% CI: 0.70–0.95), 0.91 (95% CI: 0.85–0.98) and 0.86 (95% CI: 0.78–0.95), respectively. Supplementary biomarker analyses showed lower ferritin and higher soluble transferrin receptor concentrations in the anaemia group, whereas high-sensitivity C-reactive protein did not differ between groups. These findings suggest that BCAA-related dietary characteristics may provide useful nutritional clues for anaemia-related assessment, although the association should not be interpreted as evidence of a BCAA-specific protective effect.</p> 2026-09-28T15:19:23Z Dataset Dataset 10.3389/fnut.2026.1911612.s001 https://figshare.com/articles/dataset/Table_1_Association_between_dietary_branched-chain_amino_acid_intake_and_anaemia_risk_in_children_and_adolescents_a_matched_case-control_study_docx/34015083 CC BY 4.0