2026-10-07T13:28:42Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34015022 2026-09-28T15:15:29Z category_1 category_4 category_14 category_19 category_21 category_873 category_39 category_61 category_128 portal_63 item_type_2 month_year_09_2026

Salt-Resistant Composite Colloidal Gels Stabilized by Host-Guest Interaction Shiting Zhang (8403117) Junhao Feng (16701662) Dahu Qi (9990314) Fang Yang (123514) Martien A. Cohen Stuart (25132040) Xuhong Guo (842721) Junchao Chen (4027682) Weiping Tang (419744) Junyou Wang (1488247) Tao Liu (10785) Sander C. G. Leeuwenburgh (15870424) Mingwei Wang (488863) Biophysics Biochemistry Molecular Biology Pharmacology Biotechnology Chemical Sciences not elsewhere classified Ecology Developmental Biology Hematology regenerative medicine due promising new strategy oppositely charged particles high ionic strength extending biomedical applicability excellent viscoelastic properties cell culture medium attracted great attention attractive electrostatic interactions gelatin nanoparticles functionalized dimensional networks formed guest interactions work provides tissue engineering promote proliferation physiological fluids nacl solutions l929 cells gel instability either β building blocks Colloidal gels are three-dimensional networks formed by nanoparticles, which have attracted great attention for applications in tissue engineering and regenerative medicine due to their excellent viscoelastic properties. Usually, they are formed by attractive electrostatic interactions between oppositely charged particles. However, high ionic strength of physiological fluids may disrupt the networks by screening electrostatic interactions resulting in gel instability, thereby limiting practical applicability. Herein, we report the fabrication of novel colloidal gels stabilized by host-guest interactions between gelatin nanoparticles functionalized with either β-cyclodextrin or adamantane as building blocks. These host-guest stabilized colloidal gels exhibit repeatable self-healing capability (∼100%) in NaCl solutions of high ionic strength similar to physiological fluids (150 mM), surfactant solutions and cell culture medium. Furthermore, these gels are cytocompatible and promote proliferation and migration of HUVECs and L929 cells. Consequently, this work provides a promising new strategy for extending biomedical applicability of colloidal gels. 2026-09-28T00:00:00Z Dataset Media 10.1021/acs.nanolett.6c02989.s002 https://figshare.com/articles/media/Salt-Resistant_Composite_Colloidal_Gels_Stabilized_by_Host-Guest_Interaction/34015022 CC BY-NC 4.0