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oai:figshare.com:article/34012968 2026-09-28T10:26:58Z category_7 portal_147 item_type_3 month_year_09_2026

Supplemental Material for:Post-90-day survival after stroke according to 90-day functional outcome in the 2013 and 2020 cohorts: a Swedish Stroke Register study figshare admin karger (2628495) Marcus Johnsson (25121757) Björn M. Hansen (9025529) Trine Apostolaki-Hansson (9180095) Mats Pihlsgård (4641550) Bo Norrving (162208) Teresa Ullberg (6881027) Medicine medicine <p dir="ltr"><b>Introduction </b>Ninety-day functional outcome is a strong predictor of long-term survival after stroke, but whether survival differs across calendar-year cohorts within a national stroke population at similar levels of post-stroke disability remains unclear. We therefore examined whether long-term survival from 90 days to 3 years after stroke differed between 2013 and 2020, stratified by functional outcome at 90 days.</p><p dir="ltr"><b>Methods </b>In this nationwide register-based cohort study using the Swedish Stroke Register (Riksstroke), we included patients with ischemic stroke (IS) or intracerebral hemorrhage (ICH) admitted in 2013 or 2020 who were prestroke independent (mRS 0-2) and survived 90 days. The primary outcome was all-cause mortality between day 90 and 3 years after stroke. Multivariable Cox regression models estimated adjusted hazard ratios (aHRs) and assessed whether the association between calendar-year cohort and mortality differed by 90-day mRS.</p><p dir="ltr"><a href="" target="_blank"><b>Results</b></a><b> </b>Among 27 452 patients (24 574 IS and 2 878 ICH), adjusted 3-year survival improved for 90-day survivors in 2020 compared with 2013 after IS (aHR 0.86, 95% CI 0.80–0.92), whereas no improvement was observed after ICH (aHR 0.98, 95% CI 0.80–1.19). In IS, higher survival in 2020 was observed both among functionally independent patients (mRS 0-2; aHR 0.76, 95% CI 0.68–0.86; 3-year survival 93.4% vs 91.9%) and those with dependency at 90 days (mRS 3-5; aHR 0.84, 95% CI 0.77–0.91; 76.3% vs 71.7%). In contrast, survival was not significantly different after ICH (mRS 0-2: 90.7% vs 91.1%; mRS 3-5: 78.5% vs 77.8%). Across both stroke subtypes, 90-day disability remained strongly associated with long-term mortality.</p><p dir="ltr"><b>Conclusion </b>Post-90-day survival after IS was higher in the 2020 than the 2013 cohort and was observed across the full spectrum of post-stroke disability. Findings suggest that gains in survival are not limited to patients with favorable recovery but extend across levels of post-stroke disability, potentially reflecting improvements in post-acute stroke care and secondary prevention. In contrast, no corresponding improvement was observed across functional outcome levels after ICH.<b> </b>Further studies are needed to confirm these findings and investigate their underlying mechanisms.</p> 2026-09-28T10:26:58Z Dataset Dataset 10.6084/m9.figshare.34012968.v1 https://figshare.com/articles/dataset/Supplemental_Material_for_Post-90-day_survival_after_stroke_according_to_90-day_functional_outcome_in_the_2013_and_2020_cohorts_a_Swedish_Stroke_Register_study/34012968 CC BY 4.0