2026-10-14T05:33:27Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34012767 2026-09-28T09:55:49Z category_7 portal_147 item_type_3 month_year_09_2026

Supplemental Material for: Cell Regulation, Metabolic, Inflammatory, and Hormone Signaling RNA Transcriptomic Pathways are Upregulated Among Patients with Coronary Microvascular Dysfunction and Ischemia with Non-Obstructive Coronary Arteries figshare admin karger (2628495) Barbara Jerome (25121554) Florencia Schlamp (3318885) Anaïs Hausvater (25121561) Amanda Joa (25121567) Claudia Serrano-Gomez (25121569) Ayman Farid (25121573) Tessa Barrett (25121575) Harmony R Reynolds (25121581) Jeffrey S Berger (25121583) Nathaniel R Smilowitz (25121585) Medicine Medicine <p dir="ltr"><b>Introduction</b>: Mechanisms underlying coronary microvascular dysfunction (CMD), a known cause of ischemia with non-obstructive coronary arteries (INOCA), are not well understood. <b>Methods</b>: In a prospective cohort study, we investigated the whole-blood transcriptome of 28 female patients with INOCA who underwent clinically indicated invasive coronary angiography to identify pathways relevant to the pathophysiology of CMD. <b>Results</b>: Four protein coding genes related to cell signaling and metabolism were differentially expressed and 47 transcriptomic pathways related to cell signaling, metabolism, inflammation, and sex hormone signaling were primarily upregulated with greater coronary microvascular dysfunction. <b>Conclusion</b>: Our findings support the hypothesis that inflammation leads to maladaptive microvascular remodeling and fibrosis, contributing to the pathogenesis of CMD.</p> 2026-09-28T09:55:49Z Dataset Dataset 10.6084/m9.figshare.34012767.v1 https://figshare.com/articles/dataset/Supplemental_Material_for_Cell_Regulation_Metabolic_Inflammatory_and_Hormone_Signaling_RNA_Transcriptomic_Pathways_are_Upregulated_Among_Patients_with_Coronary_Microvascular_Dysfunction_and_Ischemia_with_Non-Obstructive_Coronary_Arteries/34012767 CC BY 4.0