2026-10-14T04:52:41Z
https://api.figshare.com/v2/oai
oai:figshare.com:article/34010398
2026-09-28T06:41:11Z
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month_year_09_2026
Phytochemical characterization and bioactivity of <i>Symplocos racemosa</i> bark against psoriatic inflammation: in silico and <i>In vitro</i> insights
Sheetal Patil (20235160)
Archana Patil (791976)
Krutuja Chougule (17703822)
Biochemistry
Medicine
Genetics
Molecular Biology
Neuroscience
Pharmacology
Biotechnology
Chemical Sciences not elsewhere classified
Ecology
Immunology
Biological Sciences not elsewhere classified
Cancer
Infectious Diseases
Symplocos racemosa
psoriasis
network pharmacology
molecular dynamics
antiproliferative activity
<p>Psoriasis, an immune-mediated dermatosis marked by aberrant keratinocyte proliferation and dysregulated inflammatory cascades, demands the development of safer therapeutics. Natural products, owing to their multi-target pharmacological potential and favourable safety profiles, are increasingly investigated as alternatives to conventional synthetic agents. In the present study <i>Symplocos racemosa</i> Roxb<i>. (S. racemosa),</i> traditionally utilised in dermatotherapeutic practices, was systematically evaluated for its antipsoriatic potential. The ethanolic stem bark extract was characterised using LC–MS, which revealed the presence of several bioactive phytoconstituents, with major compounds including Baicalin, <i>N</i>-fructosyl tyrosine, and delphinidin derivatives. Molecular docking demonstrated strong target, with binding affinities of −11.77 kcal/mol (6IQ6), −10.17 kcal/mol (3CQU), and −8.23 kcal/mol (2AZ5). Molecular dynamics simulations confirmed stable protein–ligand interactions. <i>In vitro</i> cytotoxicity assessment on human keratinocytes (HaCaT) revealed an IC<sub>50</sub> of approximately 849.80 µg/mL with anti-proliferative activity. These findings highlight <i>S. racemosa</i> bark extract as multi-target modulator of psoriasis-associated molecular pathways.</p>
2026-09-28T06:41:11Z
Dataset
Dataset
10.6084/m9.figshare.34010398.v1
https://figshare.com/articles/dataset/Phytochemical_characterization_and_bioactivity_of_i_Symplocos_racemosa_i_bark_against_psoriatic_inflammation_in_silico_and_i_In_vitro_i_insights/34010398
CC BY 4.0