2026-10-14T04:36:06Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34010370 2026-09-28T06:26:37Z category_21 portal_316 item_type_3 month_year_09_2026

Table 1_Functional personalization in digital manufacturing: a translational framework for patient-specific implants, arthroscopic locators, and therapeutic constructs.xlsx Qun Li (222962) Yi-Han Yang (6092630) Jin-Wei Chu (25120491) Xu-Yang Wang (9107903) Song-Ying Du (25120494) Hong-Gang Zhu (25120497) Huai-Yu Yang (7874489) Biotechnology 3D printing anterior cruciate ligament reconstruction arthroscopic locator artificial intelligence digital manufacturing digital twin knee arthroscopy patient-specific implant <p>Three-dimensional printing and digital manufacturing are increasingly used to produce patient-specific implants, surgical guides, arthroscopic locators, and therapeutic constructs. Yet the field is often described through a device-centered lens, emphasizing anatomical customization, printing accuracy, and material feasibility. This framing is becoming insufficient. Patient-specific manufacturing should not be understood merely as the fabrication of individualized objects, but as a clinically executable workflow that translates imaging data into surgical action, regenerative therapy, and outcome-informed iteration. This Perspective proposes that the next stage of 3D printing in medicine depends on three conceptual shifts: from anatomical matching to functional and procedural optimization; from passive printed products to interfaces that carry digital planning into the operating room; and from isolated fabrication success to clinically validated, regulation-aware, and feedback-driven manufacturing systems. Orthopedic applications are used as a representative context, with particular attention to 3D-printed arthroscopic locators for knee arthroscopic anterior cruciate ligament reconstruction. This example illustrates how patient-specific design can move beyond open reconstruction into minimally invasive procedures, where accurate localization, reproducibility, and workflow compatibility are central. We further discuss therapeutic constructs, artificial intelligence, digital twins, point-of-care manufacturing, and translational barriers. Rather than offering another broad review of 3D printing applications, this Perspective proposes a framework for defining success in patient-specific digital manufacturing as the reliable conversion of patient data into safe, reproducible, and clinically meaningful intervention.</p> 2026-09-28T06:26:37Z Dataset Dataset 10.3389/fbioe.2026.1903071.s001 https://figshare.com/articles/dataset/Table_1_Functional_personalization_in_digital_manufacturing_a_translational_framework_for_patient-specific_implants_arthroscopic_locators_and_therapeutic_constructs_xlsx/34010370 CC BY 4.0