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oai:figshare.com:article/34010367 2026-09-28T06:26:37Z category_15 portal_316 item_type_3 month_year_09_2026

Data Sheet 1_Effects of transcranial direct current stimulation on gait and balance under dual-task conditions in older adults: a systematic review and meta-analysis.docx Yunxing Bi (25120482) Hongjie Ni (25120485) Ziqing Hou (25120488) Jinghua Qian (1310085) Neuroscience balance dual-task cost dual-task gait dual-task performance meta-analysis older adults systematic review transcranial direct current stimulation Objective<p>This systematic review and meta-analysis evaluated the effects of transcranial direct current stimulation (tDCS) on gait and balance outcomes measured under dual-task (DT) conditions in older adults.</p>Methods<p>Following PRISMA guidance, four databases were searched through October 13, 2025. Random-effects meta-analyses used Hedges’ g. Healthy older adults were prespecified as the primary population; clinical populations were analysed separately and mixed-population estimates were treated as exploratory. Multi-arm estimates were consolidated at the study level. Crossover trials used an assumed within-participant correlation (corr) of 0.50, with sensitivity analyses at 0.25 and 0.75. Risk of bias was assessed with RoB 2 and certainty with GRADE.</p>Results<p>Fifteen studies involving 385 participants were included, and 12 contributed to quantitative synthesis. The forest plots present exploratory mixed-population estimates: dual-task gait speed was not significantly improved (Hedges’ g = 0.071, 95% CI -0.199 to 0.340; p = 0.607), whereas the dual-task cost (DTC) of gait speed was reduced (Hedges’ g = −0.362, 95% CI -0.538 to −0.185; p < 0.001). Exploratory reductions were also observed for DTC of sway speed, sway area, and DTC of sway area. In the prespecified healthy-older-adult primary analysis, gait speed (Hedges’ g = 0.200, 95% CI 0.017 to 0.383; p = 0.032) and its DTC (Hedges’ g = −0.368, 95% CI -0.557 to −0.179; p < 0.001) favoured tDCS. The gait-speed result was sensitive to the assumed crossover correlation, whereas gait-speed DTC remained significant across correlation assumptions.</p>Conclusion<p>In healthy older adults, tDCS may improve gait speed and reduce its dual-task cost, but the gait-speed inference depends on the assumed crossover correlation and both estimates are based on only two studies. Evidence for other gait, variability, mobility, and standing-balance outcomes was inconclusive or could not be pooled within the healthy population. Evidence regarding falls, long-term benefit, and safety remains insufficient.</p>Systematic review registration<p>https://www.crd.york.ac.uk/PROSPERO/view/CRD420251206965, PROSPERO Unique Identifier: CRD420251206965.</p> 2026-09-28T06:26:37Z Dataset Dataset 10.3389/fnagi.2026.1924261.s001 https://figshare.com/articles/dataset/Data_Sheet_1_Effects_of_transcranial_direct_current_stimulation_on_gait_and_balance_under_dual-task_conditions_in_older_adults_a_systematic_review_and_meta-analysis_docx/34010367 CC BY 4.0