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oai:figshare.com:article/34009989 2026-09-28T05:48:59Z category_427 portal_316 item_type_3 month_year_09_2026

Table 2_A systematic review and meta-analysis of the effects of non-pharmacological interventions in improving psychological status and sleep quality among hemodialysis patients.docx Minjie Liu (636289) Haixia Chen (241394) Yunyun Liu (538796) Yaya Xi (21562682) Jing Su (23377) Juanping Zhong (13240268) Xinman Dou (13240271) Xinglei Wang (13240265) Public Health and Health Services not elsewhere classified anxiety depression Maintenance hemodialysis meta-analysis non-pharmacological interventions sleep quality systematic review Background<p>Patients receiving maintenance hemodialysis (MHD) experience substantial physical and psychological burdens. Non-pharmacological interventions have been increasingly explored as potential approaches for improving psychological symptoms and sleep quality in this population.</p>Objective<p>To systematically evaluate the effects of non-pharmacological interventions on depression, anxiety, and sleep quality in patients receiving MHD.</p>Methods<p>Systematic searches were conducted in PubMed, Embase, CINAHL Complete, Cochrane Library, and Web of Science from January 2000 to February 2026 for English-language randomized controlled trials (RCTs). The Cochrane Risk of Bias 2 (RoB 2) tool was used to assess the risk of bias in included trials. Standardized mean differences (SMDs) with 95% confidence intervals (CIs) were used as effect estimates for continuous outcomes. The Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach was used to assess the certainty of evidence. Meta-analyses were performed using RevMan 5.4 and R version 4.5.2.</p>Result<p>Fourteen randomized controlled trials were included. Meta-analyses comprised 9 studies (570 participants) for depression, 11 studies (647 participants) for anxiety, and 14 studies (871 participants) for sleep quality. Compared with usual care, non-pharmacological interventions significantly improved depression (SMD = −0.62, 95% CI: −0.87 to −0.37, I² = 52%), anxiety (SMD = −0.86, 95% CI: −1.23 to −0.49, I² = 79%), and sleep quality (SMD = −0.94, 95% CI: −1.33 to −0.55, I² = 87%). Leave-one-out sensitivity analyses did not materially reduce heterogeneity for anxiety or sleep quality. Exploratory subgroup analyses revealed no statistically significant differences in effect estimates according to intervention type or duration (P > 0.05). Potential publication bias was suggested for depression, whereas no statistically significant evidence of publication bias was identified for anxiety or sleep quality. Based on the GRADE framework, the certainty of evidence was moderate for depression and low for anxiety and sleep quality.</p>Conclusion<p>The available evidence suggests that non-pharmacological interventions may improve depressive symptoms, anxiety symptoms, and sleep quality in patients receiving MHD. However, the certainty of evidence was low for anxiety and sleep quality outcomes and moderate for depressive symptoms, and these findings should be interpreted cautiously.</p>Systematic Review Registration<p>Identifier CRD420261370746.</p> 2026-09-28T05:48:59Z Dataset Dataset 10.3389/fpubh.2026.1919741 https://figshare.com/articles/dataset/Table_2_A_systematic_review_and_meta-analysis_of_the_effects_of_non-pharmacological_interventions_in_improving_psychological_status_and_sleep_quality_among_hemodialysis_patients_docx/34009989 CC BY 4.0