2026-10-10T03:52:37Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34009860 2026-09-28T05:46:51Z category_393 portal_316 item_type_3 month_year_09_2026

Data Sheet 4_Perioperative intravenous lidocaine for the prevention of chronic postsurgical pain: a systematic review and meta-analysis of randomized controlled trials.pdf Wei-Jing Zhu (25119831) Ran An (456243) Qian-Yun Pang (14849779) Xiao-Long Liang (14849776) Foetal Development and Medicine chronic postsurgical pain intravenous lidocaine local anesthetic systemic toxicity meta-analysis neuropathic pain perioperative analgesia safety monitoring systematic review Background<p>Chronic postsurgical pain (CPSP) poses a significant clinical burden, yet the efficacy of perioperative intravenous lidocaine for its prevention remains inconclusive. This meta-analysis evaluates its preventive efficacy and administration regimens.</p>Methods<p>PubMed, EMBASE, and the Cochrane Library were searched from database inception to a prespecified cutoff of June 1, 2025; final electronic searches were run on June 8, 2025, to identify randomized controlled trials (RCTs) comparing perioperative intravenous lidocaine with placebo/standard care in adults. Primary outcomes were CPSP incidence at 3 and 6 months postoperatively.</p>Results<p>Eighteen RCTs (1,391 patients) were included. Intravenous lidocaine significantly reduced CPSP incidence (RR = 0.67; 95% CI: 0.53 to 0.85; P = 0.001) and neuropathic pain risk (RR = 0.60; 95% CI: 0.43 to 0.85; P = 0.004) at 3 months. However, the reduction in the incidence of CPSP was not statistically significant at 6 months (RR = 0.68; 95% CI: 0.41 to 1.12; P = 0.13). Exploratory subgroup analyses of CPSP incidence at 3 months showed favorable pooled estimates in selected surgery and administration-regimen categories; however, they did not demonstrate a statistically significant difference between regimen categories. Safety assessment was limited by inconsistent adverse-event reporting and limited pharmacokinetic monitoring.</p>Conclusion<p>Perioperative intravenous lidocaine reduces CPSP at 3 months, but evidence of an effect on CPSP incidence at 6 months remains inconclusive. Future trials should incorporate structured pharmacokinetic monitoring and exposure-response analyses and evaluate lidocaine's additive value alongside optimal regional anesthesia.</p>Systematic Review Registration<p>PROSPERO, https://www.crd.york.ac.uk/PROSPERO/view/CRD420251063756, identifier CRD420251063756.</p> 2026-09-28T05:46:51Z Dataset Dataset 10.3389/fmed.2026.1927770.s003 https://figshare.com/articles/dataset/Data_Sheet_4_Perioperative_intravenous_lidocaine_for_the_prevention_of_chronic_postsurgical_pain_a_systematic_review_and_meta-analysis_of_randomized_controlled_trials_pdf/34009860 CC BY 4.0