2026-10-12T00:25:54Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34009001 2026-09-28T05:19:33Z category_7 category_8 category_12 category_873 category_39 category_502 category_61 category_69 category_132 category_135 portal_63 item_type_2 month_year_09_2026

Multi-Chamber Dynamic Molecular Crystal Microcapsules for Payload Encapsulation and Controlled Release Lin Chen (54305) Fei Tong (1729285) Rizwan Ali (2819272) Imadul Islam (5101235) Mohammed N. Almtiri (20161738) Ibraheem A. Bushnak (25119617) Tian-Yi Xu (12244837) Qi Zhang (28502) Yikai Xu (578551) Hui-Yao Lin (21143077) Sheng Dai (466649) He Tian (629481) Da-Hui Qu (1608568) Rabih O. Al-Kaysi (1729288) Christopher J. Bardeen (1358100) Medicine Microbiology Cell Biology Chemical Sciences not elsewhere classified Ecology Astronomical and Space Sciences not elsewhere classified Developmental Biology Inorganic Chemistry Infectious Diseases Computational Biology stored contents ranging simple model captures sealed internal compartments remain exceptionally rare precisely engineered architectures ordered organic materials new design paradigm localized regions near limited growth coupled inducing photomechanical disintegration despite substantial advances asymmetric surfactant inhibition single crystal domain controlling crystal habit within separate chambers programmable internal architectures organic single crystals multichambered crystalline microcapsule 3 +</ sup 2 </ sub crystal matrix ruptured crystals programmable numbers microcapsule voids contained within work establishes triggered release term storage specific locations soluble dyes small molecules qualitative aspects produce microcapsules powerful route pot strategy positing diffusion payload encapsulation light irradiation including water hydrogen peroxide gives rise enabling encapsulation emergent functionalities diverse components demand release defined structures chemiluminescent reactions capability enables assembly offers Crystalline self-assembly offers a powerful route to ordered organic materials with well-defined structures and morphologies. Despite substantial advances in controlling crystal habit, organic single crystals with precisely engineered architectures, particularly those with fully enclosed internal cavities, remain exceptionally rare and challenging to fabricate. Here, we report a one-pot strategy that uses an optimized aqueous multisurfactant crystal growth approach to produce microcapsules with programmable numbers and sizes of sealed internal compartments. A simple model captures the qualitative aspects of this phenomenon by positing diffusion-limited growth coupled with asymmetric surfactant inhibition. The microcapsule voids are contained within a single crystal domain, enabling encapsulation and long-term storage of diverse components, including water-soluble dyes, hydrogen peroxide, and nanoparticles, within separate chambers of a multichambered crystalline microcapsule. The encapsulated species remain fully isolated and leak-tight for over 200 days. Visible-light irradiation (400–580 nm) causes photoactive molecules within the crystal matrix to undergo [2 + 2] photocycloaddition, inducing photomechanical disintegration at specific locations. This capability enables on-demand release of stored contents ranging from inorganic nanoparticles to small molecules. For example, the triggered release of H₂O₂ or Fe³⁺ gives rise to chemiluminescent reactions in localized regions near the ruptured crystals. This work establishes a new design paradigm for dynamic photoresponsive molecular crystals with programmable internal architectures and emergent functionalities. 2026-09-28T00:00:00Z Dataset Media 10.1021/jacs.6c12923.s004 https://figshare.com/articles/media/Multi-Chamber_Dynamic_Molecular_Crystal_Microcapsules_for_Payload_Encapsulation_and_Controlled_Release/34009001 CC BY-NC 4.0