2026-10-10T19:04:28Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34008582 2026-09-28T04:32:19Z category_696 portal_316 item_type_3 month_year_09_2026

Data Sheet 1_Diagnostic accuracy of Mycobacterium tuberculosis antigen-induced interferon-γ-inducible protein 10 for latent tuberculosis infection among high-risk groups: a systematic review and meta-analysis.pdf Lan Huang (11591) Yong Hu (171926) Qian Mao (1537072) Long Ge (511458) Xia Qiu (4112209) Genetic Immunology latent tuberculosis infection high-risk groups interferon-γ-inducible protein 10 Mycobacterium tuberculosis antigen-induced diagnostic accuracy Background<p>Latent tuberculosis infection (LTBI) affects nearly a quarter of the world’s population, yet current diagnostic tools are suboptimal. Interferon-γ-inducible protein 10 (IP-10) has been proposed as a candidate biomarker, but its diagnostic value for LTBI among high-risk groups is unclear. To address this, we performed a systematic review and meta-analysis to assess the accuracy of Mycobacterium tuberculosis (Mtb) antigen-induced IP-10 for detecting LTBI among high-risk groups.</p>Methods<p>PubMed, Web of Science, Embase, Scopus, and the Cochrane Library were searched up to April 2026. Cohort and cross-sectional studies evaluating Mtb antigen-induced IP-10 for LTBI diagnosis in high-risk groups were included. A bivariate random-effects model and a hierarchical summary receiver operating characteristic model were used to estimate and summarize the overall diagnostic performance.</p>Results<p>Nineteen articles comprising 24 studies (2,014 participants) were included. The pooled sensitivity, specificity, positive and negative likelihood ratios, diagnostic odds ratio, and area under the curve of Mtb antigen-induced IP-10 were 0.81, 0.88, 6.93, 0.21, 32.56, and 0.91, respectively, indicating good diagnostic performance of Mtb antigen-induced IP-10 for detecting LTBI among high-risk groups. The bivariate boxplot, meta-regression and subgroup analysis identified no significant source of heterogeneity.</p>Conclusion<p>Mtb antigen-induced IP-10 is a promising biomarker for detecting LTBI among high-risk groups. It may serve as a useful adjunct to IGRAs and TST, although its clinical utility requires further validation.</p>Systematic review registration<p>https://www.crd.york.ac.uk/prospero/, identifier CRD420261388089.</p> 2026-09-28T04:32:19Z Dataset Dataset 10.3389/fimmu.2026.1951983 https://figshare.com/articles/dataset/Data_Sheet_1_Diagnostic_accuracy_of_Mycobacterium_tuberculosis_antigen-induced_interferon-_-inducible_protein_10_for_latent_tuberculosis_infection_among_high-risk_groups_a_systematic_review_and_meta-analysis_pdf/34008582 CC BY 4.0