2026-10-12T12:32:20Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34008258 2026-09-28T04:30:11Z category_388 portal_316 item_type_3 month_year_09_2026

Data Sheet 1_Cystoscopic submucosal indocyanine green marking in robot-assisted radical nephroureterectomy: a multicenter cohort study.pdf Runyi Wang (19835916) Menghua Wu (333208) Haozhou Wang (22570166) Hui Liu (33624) Xin Zheng (104081) Oncology and Carcinogenesis not elsewhere classified fluorescence-guided surgery indocyanine green radical nephroureterectomy robot-assisted surgery upper tract urothelial carcinoma Background<p>Distal ureter and bladder cuff dissection can be difficult during robot-assisted radical nephroureterectomy (RA-RNU) for upper tract urothelial carcinoma (UTUC), particularly in the deep pelvis where tactile feedback is limited. We evaluated cystoscopic submucosal indocyanine green (ICG) marking around the ureteral orifice as a navigation aid for this step.</p>Methods<p>Adults who underwent RA-RNU with formal bladder cuff excision for clinically localized UTUC (≤T3, M0) at three centers between January 2019 and November 2024 were retrospectively analyzed. Outcomes were compared between submucosal ICG-guided and conventional non-ICG procedures. The primary endpoint was video-derived distal ureter and bladder cuff identification time; postoperative care-process measures were descriptive, and other perioperative and oncological outcomes were exploratory.</p>Results<p>The analysis included 82 patients (43 ICG, 39 non-ICG). The ICG group was older, and the largest baseline imbalances by SMD involved age and pathological T stage. Median identification time was 9.0 min with ICG and 19.3 min without ICG (p < 0.001). In the primary parsimonious model, the geometric mean ratio was 0.49 (HC3 95% CI 0.45–0.53; p < 0.001). No statistically significant between-group difference was observed in Clavien–Dindo grade. During exploratory follow-up, intravesical recurrence occurred in 1/43 versus 2/39 patients and extravesical recurrence in 3/43 versus 8/39; event counts were insufficient for comparative inference.</p>Conclusions<p>Submucosal ICG marking around the ureteral orifice was associated with faster distal ureter and bladder cuff identification during RA-RNU. Prospective studies are needed to confirm reproducibility and evaluate injection-specific safety and longer-term oncological outcomes.</p> 2026-09-28T04:30:11Z Dataset Dataset 10.3389/fonc.2026.1957208.s003 https://figshare.com/articles/dataset/Data_Sheet_1_Cystoscopic_submucosal_indocyanine_green_marking_in_robot-assisted_radical_nephroureterectomy_a_multicenter_cohort_study_pdf/34008258 CC BY 4.0