2026-10-13T09:47:30Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34007820 2026-09-28T04:23:01Z category_393 portal_316 item_type_3 month_year_09_2026

Table 4_Systematic analysis of echinocandin-associated adverse reactions using the FAERS database: identification of unique DRESS and resistance signals.xlsx Xue Zhang (166886) Ji Nie (1740730) Yuanchun Xie (25119081) Ya Ran (21195878) Hanhan Zhou (5181092) Bin Li (39349) Foetal Development and Medicine adverse drug reactions caspofungin echinocandins FAERS pharmacovigilance Aim<p>This pharmacovigilance study analyzed echinocandin-related adverse events (AEs) using the FDA Adverse Event Reporting System (FAERS) database to identify agent-specific safety signals and inform clinical decision-making.</p>Methods<p>AE reports were extracted from FAERS covering Q1 2004 to Q4 2025. Four disproportionality algorithms—reporting odds ratio (ROR), proportional reporting ratio (PRR), information component (IC025), and empirical Bayesian geometric mean (EBGM05)—were applied. Positive signals were defined when all four methods yielded positive results.</p>Results<p>A total of 5,298 cases with echinocandins as the primary suspect drug were included. Caspofungin showed unique association with DRESS syndrome (ROR = 16.62, IC025 = 3.21). Exceptionally strong resistance signals were detected for caspofungin (“pathogen resistance”: ROR = 68.83; “drug resistance”: ROR = 22.32) and micafungin (“bronchopulmonary aspergillosis”: ROR = 71.99; “Candida infection”: ROR = 23.93). Hepatobiliary signals included cholestasis (ROR = 24.97) and alkaline phosphatase increase (ROR = 19.10) for caspofungin, with similar signals observed for micafungin and anidulafungin.</p>Conclusion<p>This pharmacovigilance study identified two clinically significant signals: DRESS as a unique safety concern for caspofungin, and striking resistance signals for caspofungin and micafungin. These findings emphasize the need for vigilant monitoring during echinocandin therapy and reinforce antifungal stewardship.</p> 2026-09-28T04:23:01Z Dataset Dataset 10.3389/fmed.2026.1957674.s004 https://figshare.com/articles/dataset/Table_4_Systematic_analysis_of_echinocandin-associated_adverse_reactions_using_the_FAERS_database_identification_of_unique_DRESS_and_resistance_signals_xlsx/34007820 CC BY 4.0