2026-10-06T13:05:11Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34004685 2026-09-27T11:26:28Z category_30331 category_24748 item_type_3 month_year_09_2026

Synapse-enriched lncRNAs are required for local translation and hippocampal-dependent fear memory Sarbani Samaddar (9292799) Balakumar Srinivasan (9271115) Kamakshi Garg (21375442) Nandu Raj (25115814) Sania Sultana (18838432) Utsav Mukherjee (25115820) Dipanjana Banerjee (12487291) Wei-Siang Liau (17278144) Jian Xue (145753) Yangxi Lin (25115836) Dasaradhi Palakodeti (173941) Timothy W. Bredy (24667027) Sourav Banerjee (18838420) Behavioural neuroscience Neurosciences not elsewhere classified long non-coding RNAs(lncRNAs) RNA binding proteins (RBPs) Local translation Synapse development Memory <p dir="ltr">Studies on neuronal long noncoding RNAs (lncRNAs) have remained predominantly nucleus-centric, leaving the identity and the functional landscape of synapse-enriched lncRNAs underexplored.We identify 95 synapse-enriched lncRNAs in the adult mouse hippocampus and outline the physiological roles of the synaptic lncRNAs Pvt1,Pantr1and a previously uncharacterized synaptic lncRNA 241000H16Rik (which we call SynLAMP), in contexts of synapse development, synaptic plasticity and memory. Pvt1 exclusively regulates excitatory synapse development, and its synapse-specific loss alters synaptic activity keeping fear-memory unaltered. Contrastingly, SynLAMP demonstrates a more synapse-centric role in activity-dependent translation and fear memory. Fear-conditioning enhances SynLAMP abundance in the dendrites, where it promotes local translation by sequestering the translation inhibitor FUS. Synaptic loss of SynLAMP, or disruption in its FUS interaction impairs fear-memory and the activity-dependent local translation of CaMK2α, a FUS target. Enhanced allocation of SynLAMP to the synapse and its dynamic interaction with FUS suggests that SynLAMP behaves as an activity-dependent, synapse-localized molecular decoy that bolsters fear memory. Collectively, this study provides a mechanistic introspection on the pervasive influence of synapse-localized lncRNAs in aspects of synapse development, activity-dependent local translation, and memory formation, highlighting a stronger demand to understand the role of localized lncRNAs in broader cellular contexts.</p> 2026-09-27T11:26:28Z Dataset Dataset 10.6084/m9.figshare.34004685.v1 https://figshare.com/articles/dataset/Synapse-enriched_lncRNAs_are_required_for_local_translation_and_hippocampal-dependent_fear_memory/34004685 CC BY 4.0