2026-10-14T08:17:42Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34003473 2026-09-26T14:48:35Z category_7 category_19 category_873 category_46 category_734 category_64 category_132 portal_87 item_type_3 month_year_09_2026

Long-Term Follow-Up of Checkpoint Inhibitor-Associated Uveitis Treated with Fluocinolone Acetonide Intravitreal Implant in a Pediatric Patient Roselind L. Ni (23743147) Lauren Diroff (25114665) Robert A. Sisk (6658529) Veeral Shah (25114668) Lindsay Haacker (25114671) Brian Turpin (758626) Virginia A. Miraldi. Utz (25114674) Medicine Pharmacology Chemical Sciences not elsewhere classified Immunology Biological Sciences not elsewhere classified Cancer Infectious Diseases Fluocinolone acetonide implant immune checkpoint inhibitor pediatric uveitis steroid-induced glaucoma uveitis <p>To describe the clinical course and 2-year follow-up of a pediatric patient treated with 0.18 mg fluocinolone acetonide intravitreal implants (Yutiq, EyePoint Pharmaceuticals) for chronic, bilateral immune checkpoint inhibitor (ICI)-associated uveitis.</p> <p>Retrospective case report.</p> <p>A 15-year-old female patient with advanced epithelioid peritoneal mesothelioma on pembrolizumab and ipilimumab therapy developed chronic, bilateral ICI-associated anterior and intermediate uveitis failing topical corticosteroids was treated with bilateral intravitreal 0.18 mg fluocinolone acetonide implants, avoiding systemic immunosuppression. One year later, severe steroid-induced ocular hypertension (IOP) OS developed after receiving high-dose systemic corticosteroids for life-threatening ICI-related rhabdomyolysis. Goniotomy controlled IOP, and cataract extraction 3 months later led to visual recovery.</p> <p>The intravitreal fluocinolone acetonide 0.18 mg implant may be an effective treatment for recalcitrant ICI-associated intermediate uveitis in the pediatric population, providing long-term control of inflammation while preserving immunotherapy effectiveness. Careful follow-up is needed to monitor for complications of uveitis and corticosteroid treatment.</p> 2026-09-26T14:48:35Z Dataset Dataset 10.6084/m9.figshare.34003473.v1 https://figshare.com/articles/dataset/Long-Term_Follow-Up_of_Checkpoint_Inhibitor-Associated_Uveitis_Treated_with_Fluocinolone_Acetonide_Intravitreal_Implant_in_a_Pediatric_Patient/34003473 CC BY 4.0