2026-10-11T20:21:56Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34002866 2026-09-26T12:14:42Z category_7 category_106 category_45 category_734 portal_87 item_type_3 month_year_09_2026

A systematic review and meta-analysis of randomized controlled trials to investigate the impact of active body-weight-supported treadmill training on gait function of children and adolescents with cerebral palsy Shahla Azizi (22980152) Meysam Mansouri (22980149) Parmida Moradi Birgani (25114271) Medicine Science Policy Sociology Biological Sciences not elsewhere classified Anti-gravity treadmill body-weight-supported treadmill cerebral palsy neuroplasticity gait To study the efficacy of active body-weight-supported treadmill training (BWSTT) on gait speed, endurance, step and stride length, cadence, mobility, brain integrity, and function in children with cerebral palsy (CP). ScienceDirect, Scopus, MEDLINE, Cochrane, PEDro, CINAHL, Web of Science and Google Scholar were searched on July 15th, 2026. Randomized controlled trials (RCTs) that used BWSTT and assessed gait and brain activity were investigated. Risk of bias was assessed using ROB2. Seventeen studies were reviewed. Most studies were rated as having some concerns in risk of bias assessment. Gross motor function measure (GMFM) dimension D (MD = 3.3; p = 0.002) and E (MD = 2.56; p < 0.001) improved significantly after active BWSTT. No changes were observed in mobility, speed, stride length, cadence, and endurance. The certainty of the evidence for speed, endurance, TUG, stride length, and cadence was very low, and for GMFM was low. Active BWSTT may produce clinically relevant improvements in GMFM of children and adolescents with CP, whereas its effects on broader walking performance and underlying neural mechanisms remain uncertain. However, the low to very low certainty of evidence warrants further high-quality RCTs examining gait outcomes, brain plasticity, and their relationship. The aim of this study was to determine the efficacy of active body-weight supported treadmill training for children with cerebral palsy.There is evidence showing significant improvements in standing and walking.The training was safe without any reported adverse effects.Clinicians should remain cautious in implementing this training due to the very low certainty of the evidence. The aim of this study was to determine the efficacy of active body-weight supported treadmill training for children with cerebral palsy. There is evidence showing significant improvements in standing and walking. The training was safe without any reported adverse effects. Clinicians should remain cautious in implementing this training due to the very low certainty of the evidence. 2026-09-26T12:14:42Z Dataset Dataset 10.6084/m9.figshare.34002866.v1 https://figshare.com/articles/dataset/A_systematic_review_and_meta-analysis_of_randomized_controlled_trials_to_investigate_the_impact_of_active_body-weight-supported_treadmill_training_on_gait_function_of_children_and_adolescents_with_cerebral_palsy/34002866 CC BY 4.0