2026-10-12T22:41:14Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34000296 2026-09-25T17:52:34Z category_146 category_7 category_8 category_21 category_272 category_46 category_734 category_64 category_132 portal_5 item_type_3 month_year_09_2026

<p>Summary of post-infection euthanasia day and lung <i>M.tb</i> bacterial burden across disease states. Euthanasia day and lung CFU ranges are shown for Progressors (n = 15), Asymptomatic (n = 17), and Controllers (n = 16). Values represent the range and mean (μ) for each group. Bacterial burden is reported as CFU per lung. Progressors were euthanized within 60 days of infection reflecting acute pulmonary TB; Asymptomatic mice showed no clinical signs of disease; and Controllers were euthanized after 60 days reflecting chronic pulmonary TB.</p> Usama Sajjad (25111695) Nicholas A. Crossland (5500244) Metin N. Gurcan (5095118) Gillian Beamer (623385) Muhammad Khalid Khan Niazi (5095121) Space Science Medicine Microbiology Biotechnology Environmental Sciences not elsewhere classified Immunology Biological Sciences not elsewhere classified Cancer Infectious Diseases second novel approach granuloma architecture varies based spatial immunoprofiling multiplexed fluorescence images used lung sections results help establish derived results shows balanced immune expression tb ), caused large language model div >< p address knowledge gaps peribronchiolar b cells bronchiolar epithelial cells chronic pulmonary tb acute pulmonary tb mycobacterium tuberculosis </ b cells chronic tb multiplexed immunofluorescence immune cells bronchiolar epithelium tb </ highest immune tb -</ acute tb cells closer study show macrophage proximity low cellularity human responses higher cd4 first developed dysfunctional responses disease state directly studied deep learning better understand automated pipeline approximately 10 analyze data accurate model >), remains <p>Summary of post-infection euthanasia day and lung <i>M.tb</i> bacterial burden across disease states. Euthanasia day and lung CFU ranges are shown for Progressors (n = 15), Asymptomatic (n = 17), and Controllers (n = 16). Values represent the range and mean (μ) for each group. Bacterial burden is reported as CFU per lung. Progressors were euthanized within 60 days of infection reflecting acute pulmonary TB; Asymptomatic mice showed no clinical signs of disease; and Controllers were euthanized after 60 days reflecting chronic pulmonary TB.</p> 2026-09-25T17:52:22Z Dataset Dataset 10.1371/journal.pone.0358334.t001 https://figshare.com/articles/dataset/_p_Summary_of_post-infection_euthanasia_day_and_lung_i_M_tb_i_bacterial_burden_across_disease_states_Euthanasia_day_and_lung_CFU_ranges_are_shown_for_Progressors_n_15_Asymptomatic_n_17_and_Controllers_n_16_Values_represent_the_range_and_mea/34000296 CC BY 4.0