2026-10-10T08:24:59Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34000233 2026-09-25T17:51:53Z category_12 category_15 category_19 category_21 category_46 category_61 category_64 category_106 category_122 category_132 category_134 portal_5 item_type_3 month_year_09_2026

<p>Characteristics of the included studies.</p> Yan-Fang Peng (25111686) Xi Chen (35903) Guo-Qing Zhu (298733) Guang-Cai Qu (25111689) Cell Biology Neuroscience Pharmacology Biotechnology Immunology Developmental Biology Cancer Science Policy Mental Health Infectious Diseases Virology randomized controlled trials least 11 weeks hedges &# 8217 calculated using random achieving significant benefit mild cognitive impairment 11 weeks intervention shaped pattern suggests significant pooled effect 3400 minutes ), xlink "> twenty shaped cumulative dose processing speed showed analysis </ p global cognition exhibited shaped weekly dose g effect sizes body exercise intervention xlink "> mind xlink "> processing speed global cognition body exercise extending intervention cognitive function weekly doses similar pattern 05 ), specific dose nonlinear dose systematically searched systematic review study aimed still yielded september 15 quantify domain prospective validation older adults memory followed low certainty effects models adopted clinically 78 ]) <div> <p>Objective</p><p>This study aimed to quantify domain-specific dose-response relationships between mind-body exercise and cognitive function in older adults with mild cognitive impairment (MCI), and to derive actionable dosing recommendation.</p> <p>Methods</p><p>Eight major electronic databases were systematically searched up to September 15, 2025. Randomized controlled trials (RCTs) of mind-body exercise intervention in individuals aged ≥60 years with MCI that reported at least one cognitive domain outcome were included. Hedges’g effect sizes were calculated using random-effects models, and dose-response relationships were examined using restricted cubic spline regression.</p> <p>Results</p><p>Twenty-seven RCTs (2034 participants) were included. Moderate-certainty evidence supported improvements in global cognition (Hedges’ g: 0.67, 95% CI: [0.49, 0.78]) and processing speed (0.45 [0.3, 0.6]). Global cognition exhibited a U-shaped weekly dose-response, with 240 min/week as the relative nadir that still yielded a significant pooled effect (0.37; [0.19, 0.55]); longer intervention durations significantly amplified this overall response (β = 0.012, p < 0.05), and achieving significant benefit at this dose required ≥11 weeks intervention. Memory followed a similar pattern, but with very low certainty. Processing speed showed a U-shaped cumulative dose-response (nadir: 3400 minutes), and this effect was attenuated by weekly dose (β = −0.0011, p < 0.05), yet caution is warranted because the weekly doses in the included studies were heavily clustered.</p> <p>Conclusions</p><p>Mind-body exercise produces domain-specific dose-response patterns in older adults with MCI. For global cognition, the observed U-shaped pattern suggests that if 240 min/week dose is adopted clinically, extending intervention to at least 11 weeks is advisable. However, prospective validation of these findings is needed before clinical application.</p></div> 2026-09-25T17:51:42Z Dataset Dataset 10.1371/journal.pone.0350867.t001 https://figshare.com/articles/dataset/_p_Characteristics_of_the_included_studies_p_/34000233 CC BY 4.0