2026-10-14T09:32:58Z
https://api.figshare.com/v2/oai
oai:figshare.com:article/33998617
2026-09-25T17:33:26Z
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item_type_3
month_year_09_2026
<p>Sample size calculations.</p>
Insung Kang (608313)
Semi Park (2213920)
Yidan Zhang (130332)
Steven Tanner McCullough (25111288)
Tia LaFavor (25111291)
Yike Shen (3578180)
June Young Park (25111294)
Medicine
Biotechnology
Chemical Sciences not elsewhere classified
Developmental Biology
Science Policy
Infectious Diseases
xlink "> findings
volatile organic compounds
improving health outcomes
energy recovery ventilators
affect erv installation
80 households across
portable air cleaners
air cleaning interventions
provide important evidence
including particulate matter
related health outcomes
initial housing assessments
iaq ); however
characterize occupant behaviors
outdoor air pollutants
indoor environmental exposures
randomized controlled trial
environmental exposures
occupant behaviors
air filtration
air cleaner
trial aims
gaseous pollutants
clinical evidence
airborne particulate
related quality
related factors
outdoor mold
year post
vocs ),
using low
term effectiveness
sleep quality
relative humidity
receive one
providing insights
may contribute
intervention period
housing conditions
growing body
fort worth
conducted prior
comparative effects
combining measurements
<div>
<p>Background</p><p>Evidence linking exposure to airborne particulate and gaseous pollutants, as well as mold spores, with asthma control and severity is well established. A growing body of literature has demonstrated that ventilation and air filtration can improve indoor air quality (IAQ); however, clinical evidence on their comparative health impacts remains limited. Therefore, this trial aims to evaluate the long-term effectiveness of energy recovery ventilators (ERVs) and portable air cleaners (PACs) in reducing indoor air pollutants and mold levels and improving health outcomes in individuals with asthma. Secondary objectives includes associations between housing conditions, occupant behaviors, indoor environmental exposures, and asthma-related health outcomes.</p>
<p>Methods</p><p>The AIRVAC study is a single-blind, placebo-controlled, 4-arm, parallel-group, randomized controlled trial, with a pre-intervention period of up to 1 year and a 1-year post-intervention period. Children aged 5–17 years and adults with physician-diagnosed asthma will be recruited from more than 80 households across the Dallas-Fort Worth (DFW) area in Texas. Following the pre-intervention period, each household will be randomized to receive one of four different interventions midway through the study: (1) active ERVs, (2) sham ERVs, (3) active PACs, and (4) sham PACs. Primary health outcomes include asthma control; secondary outcomes include pulmonary function, asthma-related quality of life, stress, and sleep quality. Initial housing assessments will be conducted prior to the pre-intervention period to characterize occupant behaviors and housing-related factors that may contribute to asthma exacerbations and affect ERV installation. Environmental exposures will be assessed by combining measurements of indoor and outdoor air pollutants, including particulate matter (PM), nitrogen dioxide (NO<sub>2</sub>), carbon monoxide (CO), and volatile organic compounds (VOCs), as well as temperature, relative humidity, and indoor and outdoor mold, using low-cost and research-grade air quality sensors and mold sampling methods.</p>
<p>Discussion</p><p>Findings from the AIRVAC study will provide important evidence on the comparative effects of residential ventilation and air cleaning interventions on IAQ, mold, and asthma-related health outcomes among children and adults with asthma. The study will also examine the relationships among housing characteristics, occupant behaviors, indoor environmental exposures, and asthma-related health outcomes, while providing insights into the operation and performance of residential ventilation and air cleaning interventions in vulnerable households.</p></div>
2026-09-25T17:33:22Z
Dataset
Dataset
10.1371/journal.pone.0358221.t001
https://figshare.com/articles/dataset/_p_Sample_size_calculations_p_/33998617
CC BY 4.0