2026-10-12T04:23:03Z https://api.figshare.com/v2/oai

oai:figshare.com:article/33998600 2026-09-25T17:33:18Z category_13 category_21 category_734 category_61 category_132 portal_5 item_type_3 month_year_09_2026

<p>Functional PTGS candidate classes defined by consequence-first prioritisation.</p> Reuben S. Maghembe (24764031) Genetics Biotechnology Biological Sciences not elsewhere classified Developmental Biology Infectious Diseases structured coding variation shell position adjacent peptide predictor output comparative evolutionary pharmacogenomics canonical val511 mapped calibrated prioritisation framework resolved population differentiation describe population differentiation sequence property calculations sequence missense variants regulate prostaglandin biosynthesis prediction boundary checks proline count across aware consequence annotation controlled structural analyses study integrated allele terminal ptgs1 leader residue leader sequence terminal leader residue count interpreting population structural context prediction evidence human prostaglandin controlled docking transcript consequence tested conditions systematic variant srp recognition retrospective comparison results support ranked first ptgs1 p pangolin evaluation nsaids ). nonsteroidal anti membrane insertion mean kyte major targets inflammatory drugs frequency structure frequency range er targeting enzyme activity drug response doolittle hydropathy domain mapping direct leader <p>Functional PTGS candidate classes defined by consequence-first prioritisation.</p> 2026-09-25T17:33:08Z Dataset Dataset 10.1371/journal.pone.0358222.t001 https://figshare.com/articles/dataset/_p_Functional_PTGS_candidate_classes_defined_by_consequence-first_prioritisation_p_/33998600 CC BY 4.0