2026-10-12T05:28:20Z
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oai:figshare.com:article/33997915
2026-09-25T17:25:23Z
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<p>Post-antibiotic UPEC regrowth in an OM-89-treated mouse bladder organoid.</p>
Kathrin Tomasek (25111129)
Kristina Skurvydaite (25111132)
Gauri Paduthol (25111135)
Allison M. Burns (25111138)
Léa Schlunke (21232340)
Valentin Borgeat (25111141)
Christian Pasquali (503452)
Mario Romani (25111144)
John D. McKinney (1493986)
Medicine
Microbiology
Cell Biology
Genetics
Environmental Sciences not elsewhere classified
Immunology
Biological Sciences not elsewhere classified
Cancer
Infectious Diseases
targeted lysosomal activation
reduces recurrence rates
major clinical burden
influence treatment outcomes
human epithelial models
escherichia coli </
epithelial infection models
differentiated epithelial monolayers
bacteria withstand antibiotics
multiple antibiotic classes
antibiotic bacterial regrowth
uropathogenic escherichia coli
globally used therapy
bladder epithelial cells
antibiotic therapy
intracellular uropathogenic
bladder organoids
bladder epithelium
vaxom ),
several decades
pharmacologically reinforced
limits post
host defenses
clinically approved
cellular mechanisms
<p>Related to <a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1014448#ppat.1014448.g001" target="_blank">Fig 1</a> and <a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1014448#ppat.1014448.s001" target="_blank">S1E Fig</a>. As in <a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1014448#ppat.1014448.s011" target="_blank">S1 Video</a>, for a representative mouse bladder organoid treated with OM-89. Bacterial regrowth remains reduced relative to PBS but continues to originate preferentially from the organoid wall.</p> <p>(MP4)</p>
2026-09-25T17:25:06Z
Dataset
Media
10.1371/journal.ppat.1014448.s012
https://figshare.com/articles/media/_p_Post-antibiotic_UPEC_regrowth_in_an_OM-89-treated_mouse_bladder_organoid_p_/33997915
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