2026-10-12T04:45:18Z https://api.figshare.com/v2/oai

oai:figshare.com:article/33995411 2026-09-25T13:27:36Z category_4 category_12 category_21 category_734 category_64 category_132 category_134 category_135 portal_87 item_type_3 month_year_09_2026

Prognostic value of dynamic changes in C‑reactive protein‑albumin ratio for patients with spontaneous intracerebral hemorrhage Jia Li (160557) Guo-Min Xie (5581319) Yan Mao (492639) Pan-di Chen (25110344) Guang-Yao Zhu (21074270) Geng-Fan Ye (25110347) Mao-Song Chen (25110350) Tao Song (130854) Yi Liu (36759) Biochemistry Cell Biology Biotechnology Biological Sciences not elsewhere classified Cancer Infectious Diseases Virology Computational Biology C‑reactive protein‑albumin ratio dynamic change outcome prognosis prediction spontaneous intracerebral hemorrhage <p>To examine the predictive value of the C‑reactive protein‑albumin ratio (CAR) measured at distinct time points.</p> <p>Multivariate logistic regression was applied to examine the links of CAR 1 (at admission), CAR 2 (7th day after admission), and ΔCAR (change between CAR 1 and CAR 2) with 3-month prognosis.</p> <p>CAR 2 (AUC = 0.704, 95%CI: 0.650–0.757) yielded a statistically significantly higher predictive performance for the 3-month prognosis relative to CAR 1 (AUC = 0.624, 95%CI: 0.563–0.685) and ΔCAR (AUC = 0.624, 95%CI: 0.563–0.685) (for CAR 1 or ΔCAR vs. CAR 2, both <i>p</i> < 0.05). The ICH score + CAR 2 (AUC = 0.817, 95%CI: 0.764–0.869) provided significantly increased predictive efficacy versus the ICH score alone (AUC = 0.776, 95%CI: 0.717–0.835) (<i>p</i> = 0.018). Similarly, the predictive performance of the ICH index + CAR 2 (AUC = 0.810, 95%CI: 0.762–0.859) surpassed that of the ICH index alone (AUC = 0.772, 95%CI: 0.721–0.823) (<i>p</i> = 0.004).</p> <p>CAR measured on the 7th day of admission was markedly linked to a poor 3-month prognosis and significantly increased predictive efficacy of existing prognostic scoring systems for patients with ICH. All observed associations and predictive advantages of day-7 CAR are derived from retrospective single-center data; prospective, multicenter cohort studies with independent external datasets are mandatory to verify our findings before any clinical translational use.</p> 2026-09-25T13:27:36Z Dataset Dataset 10.6084/m9.figshare.33995411.v1 https://figshare.com/articles/dataset/Prognostic_value_of_dynamic_changes_in_C_reactive_protein_albumin_ratio_for_patients_with_spontaneous_intracerebral_hemorrhage/33995411 CC BY 4.0