2026-10-06T19:06:30Z https://api.figshare.com/v2/oai

oai:figshare.com:article/33994824 2026-09-25T11:46:33Z category_64 category_384 category_385 category_386 category_388 category_387 category_379 category_380 category_381 category_382 category_383 portal_316 item_type_3 month_year_09_2026

Table_1_The Interaction of CDH20 With β-Catenin Inhibits Cervical Cancer Cell Migration and Invasion via TGF-β/Smad/SNAIL Mediated EMT.DOCX Chao Li (145513) Hongfeng Ao (8271219) Guofang Chen (2481478) Fang Wang (105926) Fang Li (41162) Cancer Haematological Tumours Molecular Targets Radiation Therapy Oncology and Carcinogenesis not elsewhere classified Solid Tumours Cancer Cell Biology Cancer Diagnosis Cancer Genetics Cancer Therapy (excl. Chemotherapy and Radiation Therapy) Chemotherapy cervical cancer cadherin 20 β-catenin cancer metastasis epithelial-to-mesenchymal transition pSmad2/3 <p>Cancer-associated cadherin 20 (CDH20) is a novel identified cadherin that is genetically altered in several types of human cancer, including cervical cancer. However, its involvement in the progression of cervical cancer remains unknown. In this study, we show that CDH20 was downregulated in clinical cervical cancer samples and its expression correlated with cervical cancer clinical features. CDH20 negatively regulated the migration and invasion of cervical cancer cells. CDH20 increased the expression and promoted the cytoplasm and membrane translocation of β-catenin, and interacted with β-catenin. Mechanistically, CDH20/β-catenin suppressed transforming growth factor-β (TGF-β)-induced epithelial-to-mesenchymal transition (EMT) by downregulating Snail through reducing the phosphorylation and nuclear translocation of Smad2/3. Taken together, our data suggest that CDH20 may act as a tumor suppressor that interacts with β-catenin to inhibit cervical cancer cell migration and invasion via TGF-β/Smad/Snail mediated EMT.</p> 2026-09-25T11:46:33Z Dataset Dataset 10.3389/fonc.2019.01481.s001 https://figshare.com/articles/dataset/Table_1_The_Interaction_of_CDH20_With_-Catenin_Inhibits_Cervical_Cancer_Cell_Migration_and_Invasion_via_TGF-_Smad_SNAIL_Mediated_EMT_DOCX/33994824 CC BY 4.0