2026-10-14T05:01:53Z https://api.figshare.com/v2/oai

oai:figshare.com:article/33994791 2026-09-25T11:32:18Z category_658 portal_316 item_type_3 month_year_09_2026

Supplementary file 1_Exploratory secondary analysis of published aggregate growth and metabolic data in children born small for gestational age treated with growth hormone.docx Huihua Yuan (1841362) Yanli Wang (120335) Zhijin Lu (25109652) Zhigang Zhang (20860) Shuyi Luo (9609173) Yan Wang (15435) Cell Metabolism aggregate data analysis ecological inference growth hormone metabolic surveillance registry research secondary analysis small for gestational age somatropin Purpose<p>To describe published annual growth and metabolic summaries for children born small for gestational age (SGA) treated with growth hormone and to define the limits of inference from aggregate registry data.</p>Methods<p>We conducted an exploratory secondary analysis of published aggregate means, standard deviations, and outcome-specific sample sizes from baseline through year 5 in the SGA subgroup of the Korean LG Growth Study, with up to 318 children represented at baseline. Primary reporting was descriptive and included annual values, changes from baseline, and measurement availability. Exploratory slope models were retained only as supplementary sensitivity analyses. The published aggregate LGS summaries available for the present secondary analysis did not include longitudinal blood-pressure measurements or cardiovascular-event records.</p>Results<p>Height SDS was −2.38 at baseline and −0.76 at year 5, weight SDS was −2.21 and −0.84, and BMI SDS was −0.93 and −0.64. The published mean AST was 32.07 IU/L at baseline and 24.28 IU/L at year 5, whereas several other metabolic markers had higher year-5 means. Median year-5 measurement availability was 12.8% of outcome-specific baseline counts, and only six triglyceride measurements were available at year 5. The markedly reduced outcome-specific sample sizes at later follow-up points substantially limit interpretation of long-term patterns.</p>Conclusion<p>Published annual mean values differed across follow-up, but changing outcome-specific samples and the unavailability of individual-level longitudinal data to the present secondary analysis preclude estimation of within-child change, causal treatment effects, or cardiovascular risk.</p> 2026-09-25T11:32:18Z Dataset Dataset 10.3389/fendo.2026.1942946.s001 https://figshare.com/articles/dataset/Supplementary_file_1_Exploratory_secondary_analysis_of_published_aggregate_growth_and_metabolic_data_in_children_born_small_for_gestational_age_treated_with_growth_hormone_docx/33994791 CC BY 4.0