2026-10-13T04:09:24Z https://api.figshare.com/v2/oai

oai:figshare.com:article/33994696 2026-09-25T11:10:00Z category_4 category_24 category_272 category_873 category_46 category_61 category_64 category_132 category_134 portal_63 item_type_3 month_year_09_2026

Palladium Catalyzed Radical Fluorination of Arylacetic Acid Equivalents via α‑Carbonyl Radicals Rupali Dasharath Shinde (18834646) Vimalbhai Hareshbhai Parmar (25109500) Anik Sen (1751128) Sukalyan Bhadra (1453231) Biochemistry Evolutionary Biology Environmental Sciences not elsewhere classified Chemical Sciences not elsewhere classified Immunology Developmental Biology Cancer Infectious Diseases Virology fluorine atom transfer fluorination proceeds via dft studies corroborated carbonyl radicals followed fluorinated acetic acids arylacetic acids reaction gives pyridine directed process involving induced formation experimental results expedient access A palladium catalyzed highly chemo- and site-selective radical benzylic fluorination of arylacetic acids with Selectfluor has been developed. The reaction gives an expedient access to fluorinated acetic acids with exceptional α-selectivity. The fluorination proceeds via a pyridine directed, SET-induced formation of α-carbonyl radicals followed by a fluorine atom transfer (FAT) process involving a Pd^I-intermediate. DFT studies corroborated the experimental results. 2026-09-25T00:00:00Z Dataset Dataset 10.1021/acs.joc.6c01202.s001 https://figshare.com/articles/dataset/Palladium_Catalyzed_Radical_Fluorination_of_Arylacetic_Acid_Equivalents_via_Carbonyl_Radicals/33994696 CC BY-NC 4.0