2026-10-12T00:42:56Z https://api.figshare.com/v2/oai

oai:figshare.com:article/33994593 2026-09-25T10:56:57Z category_7 portal_147 item_type_3 month_year_09_2026

Supplemental Material for: Association between intentional non-medical substance use and allergic diseases among Korean adolescents: a nationwide representative study figshare admin karger (2628495) Seohyun Lee (4383625) Juyeong Kim (1515922) Hyunjee Kim (11950539) Kyeongeun Kim (21007808) Jaeyi Shin (25109435) Seong H Cho (25109438) Jiseung Kang (16791189) Dong Keon Yon (16665981) Nikolaos G Papadopoulos (25109440) Medicine Medicine Introduction:Despite the high accessibility and persistent misuse of inhalants and other psychoactive substances among Korean youth, their association with the long-term risk of allergic diseases remains unclear. Thus, this study aimed to investigate the association between intentional non-medical substance use and the risk of three major allergic diseases (asthma, allergic rhinitis [AR], and atopic dermatitis [AD]) among Korean adolescents.Methods:We analyzed data from the Korea Youth Risk Behavior Survey, a nationally representative, school-based survey, including 740,141 adolescents aged≥ 14 yearsfrom 2008–2014 and 2016–2019. Intentional non-medical substance use was assessed via self-reported lifetime history and further categorized by recency and specific substance types, including butane gas, glues, stimulants, methamphetamine, excessive cough suppressants, or sedatives. Physician-diagnosed asthma, AR, and AD were evaluated as primary outcomes. Survey-weighted multivariable logistic regression analysis was performed to estimate adjusted odds ratios (aORs) with 95% confidence intervals (CIs), and comprehensive subgroup and stratified analyses were conducted to evaluate substance-specific effects across sociodemographic groups.Results:Among 740,141 adolescents (males, 51.39%), lifetime non-medical substance use was significantly associated with increased odds of asthma (aOR, 1.73 [95% CI, 1.60–1.87]), while the association with AR was modest (1.07 [1.00–1.13]) and no significant association was observed for AD (1.05 [0.98–1.12]). Among those reporting current occasional use of specified substances, odds of asthma exceeded twofold compared with never-users (aOR, 2.81 [95% CI, 2.37–3.35]) and were markedly higher than the odds observed among those reporting former use (1.95 [1.67–2.28]). Regarding asthma, substance users showed significantly increased odds compared with non-users in both females (aOR, 1.92 [95% CI, 1.69–2.18]) and males (1.64 [1.48–1.80]). Notably, compared with males, females showed significantly increased odds not only for asthma but also for AR (aOR, 1.25 [95% CI, 1.14–1.38]) and AD (1.16 [1.06–1.28]).Conclusion:Intentional non-medical substance use is significantly associated with an increased risk of allergic diseases among Korean adolescents. This association is particularly pronounced in females, highlighting the need for sex-specific preventative strategies and targeted public health interventions to mitigate substance-related respiratory and allergic risks in youth. 2026-09-25T10:56:57Z Dataset Dataset 10.6084/m9.figshare.33994593.v1 https://figshare.com/articles/dataset/Supplemental_Material_for_Association_between_intentional_non-medical_substance_use_and_allergic_diseases_among_Korean_adolescents_a_nationwide_representative_study/33994593 CC BY 4.0