2026-10-07T05:15:38Z https://api.figshare.com/v2/oai

oai:figshare.com:article/33994533 2026-09-25T10:17:36Z category_19 portal_316 item_type_3 month_year_09_2026

Data Sheet 1_ALKBH5 inhibitors for cancer therapy: molecular docking, challenges and future prospects.docx Chen Deng (3111333) Hai Xu (141126) Jian Pu (1822894) Huamei Wei (9591122) Wenjin Chen (5940245) Yubin Luo (494656) Shengxiao Zhang (2302840) Haifeng Jin (341817) Jie Liao (41399) Zhongpeng Fan (270845) Miaomiao Cao (12150270) Yangyang Xu (117932) Benshun Hu (25109298) Pharmacology ALKBH5 cancer therapy challenges future prospects RNA demethylase <p>N⁶-Methyladenosine (m⁶A), the most abundant internal modification of eukaryotic mRNA, is dynamically reversed by the Fe^II/α-ketoglutarate-dependent dioxygenase ALKBH5, a key m⁶A “eraser” that regulates target mRNA fate through demethylation. ALKBH5 is aberrantly overexpressed in acute myeloid leukemia, glioblastoma, breast cancer and other malignancies, where it sustains oncogenic programs, establishing it as a promising epitranscriptomic drug target. At present, ALKBH5 inhibitor development lags behind that of FTO, with selective agents only recently emerging through covalent inhibitors such as compound 33, 25 and 40, though no clinically available ALKBH5-targeted drug yet exists. This review summarizes the biological functions, structural features, and molecular docking between reported inhibitors and target proteins of ALKBH5. Current challenges, including selectivity over homologous dioxygenases, structural optimization and resistance mechanisms, are critically discussed, alongside future perspectives on structure-guided design, combination regimens and clinical translation. This review provides a medicinal chemistry framework to accelerate the discovery of potent and selective ALKBH5 inhibitors for precision cancer therapy.</p> 2026-09-25T10:17:36Z Dataset Dataset 10.3389/fphar.2026.1946973.s001 https://figshare.com/articles/dataset/Data_Sheet_1_ALKBH5_inhibitors_for_cancer_therapy_molecular_docking_challenges_and_future_prospects_docx/33994533 CC BY 4.0