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oai:figshare.com:article/33994206 2026-09-25T09:05:21Z category_1 category_4 category_8 category_14 category_24 category_272 category_873 category_734 category_132 category_135 portal_63 item_type_3 month_year_09_2026

A General Route to Silacyclohexanones via Regioselective Copper-Catalyzed Borylative Cyclization Chen-Li Jin (20401509) Ting Wu (106368) Rong-Jun Shi (25108574) Hui-Ting Chen (327178) Jun-Han Ma (16438743) Zheng Xu (162992) Li-Wen Xu (572954) Fei Ye (339913) Biophysics Biochemistry Microbiology Molecular Biology Evolutionary Biology Environmental Sciences not elsewhere classified Chemical Sciences not elsewhere classified Biological Sciences not elsewhere classified Infectious Diseases Computational Biology step oxidation sequence reaction proceeds via dft calculations corroborate catalyzed borylative cyclization broad substrate scope >- selective cyclization wittig olefination synthetic utility silicon center silacyclohexyl boronates scale capability observed selectivity membered rings including ketalization general route endo </ diverse transformations deliver 4 conformational role chloromethyl butenylsilanes afford 4 A copper-catalyzed regioselective borylative cyclization of chloromethyl butenylsilanes with bis(pinacolato)diboron has been reported. The reaction proceeds via an <i>endo</i>-selective cyclization to deliver 4-silacyclohexyl boronates, which undergo a two-step oxidation sequence to afford 4-silacyclohexanones. DFT calculations corroborate the observed selectivity, highlighting the conformational role of the silicon center in favoring the six-membered rings. This protocol features readily available starting materials, a broad substrate scope, good functional group tolerance, and gram-scale capability. The synthetic utility of the resulting silacyclohexanones is demonstrated through diverse transformations, including ketalization, allylation, Wittig olefination, and Baeyer–Villiger oxidation. 2026-09-25T00:00:00Z Dataset Dataset 10.1021/acs.orglett.6c03675.s001 https://figshare.com/articles/dataset/A_General_Route_to_Silacyclohexanones_via_Regioselective_Copper-Catalyzed_Borylative_Cyclization/33994206 CC BY-NC 4.0