2026-10-12T13:46:42Z https://api.figshare.com/v2/oai

oai:figshare.com:article/33992197 2026-09-25T04:27:40Z category_363 portal_316 item_type_3 month_year_09_2026

Table 1_Comparative effectiveness of traditional Chinese medicine treatment strategies for insomnia: a systematic review and network meta-analysis.docx Yan Liu (25061) Xiuying Wang (664529) Yaqin Zhang (408075) Yanfang Li (319649) Yini Huang (7322873) Neurology and Neuromuscular Diseases insomnia network meta-analysis sleep disorder traditional Chinese medicine formulations Western medicine Objective<p>Insomnia causes daytime impairment and reduced quality of life. We evaluated the comparative efficacy and safety of Traditional Chinese Medicine (TCM) treatment strategies for insomnia.</p>Methods<p>Nine databases (PubMed, Embase, Web of Science, Cochrane CENTRAL, ClinicalTrials.gov, CNKI, Wanfang, VIP, SinoMed) were searched through January 2026 for randomized controlled trials (RCTs). Primary outcomes were ISI and PSQI scores; secondary outcomes included clinical efficacy and adverse events (AEs). Data were synthesized using frequentist network meta-analysis.</p>Results<p>Twelve RCTs involving 1,260 participants were included, evaluating five strategy nodes: TCM alone, TCM plus Western medicine (WM), WM alone, placebo, and CBT-I. For ISI, TCM plus WM ranked highest (SUCRA 89.7%) and significantly improved scores versus placebo (OR 2.84, 95% CI 1.42–5.68) and WM (OR 1.96, 95% CI 1.08–3.56). For PSQI, TCM plus WM showed the highest probability of improvement (SUCRA 71.9%) with greater reduction versus placebo (MD −2.31, 95% CI −3.65 to −0.97). For clinical efficacy, SUCRA values were 86.6% for TCM plus WM, 77.2% for TCM, 20.9% for WM, and 15.3% for placebo. For AEs (higher SUCRA indicating better safety), SUCRA values were 94.8% for WM, 43.9% for TCM plus WM, 31.1% for placebo, and 30.2% for TCM. Sensitivity analysis excluding secondary insomnia confirmed robust findings.</p>Conclusion<p>Integrated TCM-WM and TCM therapies demonstrate clinical efficacy and acceptable safety for insomnia management.</p>Systematic review registration<p>The review protocol was prospectively registered in the International Platform of Registered Systematic Review and Meta-analysis Protocols (INPLASY) (Registration number: INPLASY202680041; DOI: 10.37766/inplasy2026.8.0041).</p> 2026-09-25T04:27:40Z Dataset Dataset 10.3389/fneur.2026.1912776.s001 https://figshare.com/articles/dataset/Table_1_Comparative_effectiveness_of_traditional_Chinese_medicine_treatment_strategies_for_insomnia_a_systematic_review_and_network_meta-analysis_docx/33992197 CC BY 4.0