2026-10-12T09:27:03Z https://api.figshare.com/v2/oai

oai:figshare.com:article/33992005 2026-09-25T04:25:18Z category_388 portal_316 item_type_3 month_year_09_2026

Table 1_Development and external validation of a nomogram to predict survival and guide surgical strategy for colorectal cancer with synchronous liver and lung metastases: a SEER-based analysis.docx Hongqing Ma (12886118) Jianfeng Zhang (219107) Qingyu Meng (832290) Zesong Meng (12044189) Weijing Li (704845) Chen Liu (75209) Guiying Wang (153514) Oncology and Carcinogenesis not elsewhere classified colorectal cancer nomogram overall survival primary tumor resection risk stratification SEER database synchronous liver and lung metastases <p>Surgical management of colorectal cancer with synchronous liver and lung metastases (CRC-SLLM) remains challenging because of marked clinical heterogeneity, and reliable tools for individualized risk assessment are lacking. We aimed to develop and externally validate a nomogram for overall survival (OS) prediction and to explore its potential value in guiding selection for primary tumor resection (PTR). Patients diagnosed with CRC-SLLM between 2010 and 2015 were identified from the Surveillance, Epidemiology, and End Results (SEER) database and randomly assigned to a training cohort (n = 808) and an internal validation cohort (n = 345) in a 7:3 ratio, whereas external validation was performed using 65 patients from the Fourth Hospital of Hebei Medical University, China. After feature selection with least absolute shrinkage and selection operator (LASSO) regression, a multivariable Cox-based nomogram was constructed, and its performance was assessed using time-dependent receiver operating characteristic curves, calibration plots, decision curve analysis (DCA), and risk stratification. The final nomogram incorporated nine predictors: age, primary tumor site, histological grade, tumor size, N stage, bone metastasis, carcinoembryonic antigen status, metastasectomy, and chemotherapy. It showed stable discrimination across the training, internal validation, and external validation cohorts, with 12-month areas under the curve (AUCs) of 0.791, 0.714, and 0.778 and 24-month AUCs of 0.742, 0.740, and 0.730, respectively; calibration was good in all cohorts, and DCA supported potential clinical utility. Nomogram-based risk stratification separated patients into prognostically distinct low- and high-risk groups, and an exploratory analysis indicated that the survival benefit of PTR was largely confined to low-risk patients. This externally validated nomogram provides individualized survival prediction and risk stratification for patients with CRC-SLLM and may help identify those more likely to benefit from PTR, although this finding remains exploratory and warrants confirmation in prospective multicenter studies.</p> 2026-09-25T04:25:18Z Dataset Dataset 10.3389/fonc.2026.1915006.s001 https://figshare.com/articles/dataset/Table_1_Development_and_external_validation_of_a_nomogram_to_predict_survival_and_guide_surgical_strategy_for_colorectal_cancer_with_synchronous_liver_and_lung_metastases_a_SEER-based_analysis_docx/33992005 CC BY 4.0