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oai:figshare.com:article/33989160 2026-09-24T17:46:04Z category_4 category_8 category_12 category_13 category_21 category_272 category_39 category_734 category_133 portal_5 item_type_3 month_year_09_2026

<p>Complete differential gene expression results for all pairwise comparisons between pyrethroid-selected and unselected <i>Aedes aegypti</i> strains.</p> Alejandro Mejía Muñoz (13767032) Ana María Mejía-Jaramillo (4425904) Carl Lowenberger (401368) Karla Saavedra-Rodríguez (369998) Omar Triana-Chávez (180595) Biochemistry Microbiology Cell Biology Genetics Biotechnology Environmental Sciences not elsewhere classified Ecology Biological Sciences not elsewhere classified Plant Biology odorant binding proteins especially cyp4 ), electron transport chain div >< p controlling dengue outbreaks article advances understanding used rna sequencing integrated response complemented aedes aegypti </ molecular mechanisms triggered elicit distinct responses identified genes involved transcriptomic response depends different insecticide concentrations classical metabolic detoxification analyzed resistance mechanisms type ii pyrethroids aegypti </ transcriptomic response increasing concentrations kdr </ response transcripts overall responses metabolic shift metabolic enzymes distinguish responses genes suggests cyp450 genes cuticle genes concentration used insecticide type insecticide spraying trna transcripts shared mode reduced penetration mutations confer mosquito populations moderate levels insecticides permethrin expression patterns exposure levels exceptional ability even sequestration detoxifying enzymes controlled permethrin common strategy chemical structure <p>Full DESeq2 output for six pairwise comparisons: high-pressure lambda-cyhalothrin resistant vs. unselected AF (HLR vs. AF), high-pressure lambda-cyhalothrin susceptible vs. AF (HLS vs. AF), low-pressure lambda-cyhalothrin vs. AF (LL vs. AF), high-pressure permethrin resistant vs. AF (HPR vs. AF), high-pressure permethrin susceptible vs. AF (HPS vs. AF), and low-pressure permethrin vs. AF (LP vs. AF). Each sheet reports, for all ~ 11,450 genes analyzed: Gene ID (VectorBase AAEL identifier), baseMean (mean normalized read count), log2 fold change (log2FC), standard error of log2FC (lfcSE), Wald statistic, p-value, adjusted p-value (padj; Benjamini-Hochberg correction), gene name, product description, and functional category. Genes are sorted by log2FC in descending order. Functional categories (CUT: cuticular proteins; and others as described in the Results) were assigned based on BLAST annotation against UniProt/SwissProt and VectorBase. Comparisons involving the AF strain used previously published RNA-seq data from Mejía et al. (2025) <i>Insects</i> 16:106.</p> <p>(XLSX)</p> 2026-09-24T17:56:33Z Dataset Dataset 10.1371/journal.pntd.0014144.s003 https://figshare.com/articles/dataset/_p_Complete_differential_gene_expression_results_for_all_pairwise_comparisons_between_pyrethroid-selected_and_unselected_i_Aedes_aegypti_i_strains_p_/33989160 CC BY 4.0