2026-10-14T02:37:21Z https://api.figshare.com/v2/oai

oai:figshare.com:article/33989154 2026-09-24T17:46:02Z category_4 category_8 category_12 category_13 category_21 category_272 category_39 category_734 category_133 portal_5 item_type_3 month_year_09_2026

<p>Pairwise comparison of enzymatic activity among <i>Aedes aegypti</i> pyrethroid-selected and unselected populations.</p> Alejandro Mejía Muñoz (13767032) Ana María Mejía-Jaramillo (4425904) Carl Lowenberger (401368) Karla Saavedra-Rodríguez (369998) Omar Triana-Chávez (180595) Biochemistry Microbiology Cell Biology Genetics Biotechnology Environmental Sciences not elsewhere classified Ecology Biological Sciences not elsewhere classified Plant Biology odorant binding proteins especially cyp4 ), electron transport chain div >< p controlling dengue outbreaks article advances understanding used rna sequencing integrated response complemented aedes aegypti </ molecular mechanisms triggered elicit distinct responses identified genes involved transcriptomic response depends different insecticide concentrations classical metabolic detoxification analyzed resistance mechanisms type ii pyrethroids aegypti </ transcriptomic response increasing concentrations kdr </ response transcripts overall responses metabolic shift metabolic enzymes distinguish responses genes suggests cyp450 genes cuticle genes concentration used insecticide type insecticide spraying trna transcripts shared mode reduced penetration mutations confer mosquito populations moderate levels insecticides permethrin expression patterns exposure levels exceptional ability even sequestration detoxifying enzymes controlled permethrin common strategy chemical structure <p>Significance of pairwise comparisons of five enzymatic activities — acetylcholinesterase (AChE), mixed-function oxidases (MFO), alpha-esterase (α-EST), beta-esterase (β-EST), and glutathione S-transferases (GST) — across lambda-cyhalothrin-selected (HL, LL), permethrin-selected (HP, LP), unselected (AF), and susceptible reference (Rockefeller) strains of <i>Ae. aegypti</i>. Statistical significance was determined using the Kruskal-Wallis test followed by Dunn's multiple comparisons test with Bonferroni correction. Asterisks indicate significance levels: * p < 0.05; ** p < 0.01; *** p < 0.001; ns, not statistically significant.</p> <p>(XLSX)</p> 2026-09-24T17:56:33Z Dataset Dataset 10.1371/journal.pntd.0014144.s001 https://figshare.com/articles/dataset/_p_Pairwise_comparison_of_enzymatic_activity_among_i_Aedes_aegypti_i_pyrethroid-selected_and_unselected_populations_p_/33989154 CC BY 4.0