2026-10-10T20:19:38Z https://api.figshare.com/v2/oai

oai:figshare.com:article/33989149 2026-09-24T17:45:57Z category_4 category_7 category_8 category_12 category_272 category_39 portal_5 item_type_3 month_year_09_2026

<p>Biologically relevant metabolites with significant variation in abundance between FBS and GS. Log₂ fold-change (FC) analysis (GS/FBS) is summarised alongside their associated P-values (<i>t</i>-test) and false discovery rate (FDR)-adjusted P-values. Positive values indicate higher abundance in GS, negative values indicate higher abundance in FBS. The full dataset is available in the supplementary results (S1 Table).</p> Emily A. Dickie (9732841) Stefan K. Weidt (13876669) Jennifer Haggarty (21392438) Gavin Blackburn (2111572) Mary K. Doherty (1892476) Ryan Ritchie (449213) Edith Paxton (5480174) Simon Young (684) Phillip D. Whitfield (1892482) Terry K. Smith (112550) Liam J. Morrison (9300330) Michael P. Barrett (167748) Pieter C. Steketee (10024552) Biochemistry Medicine Microbiology Cell Biology Environmental Sciences not elsewhere classified Ecology unified biological understanding ms lipidomics analyses likely carries implications developing experimental systems comparative lipidomic profiling african animal trypanosomosis trypanosome membrane biology one health approach bloodstream form parasites novel medium formulation relative lipidomic profiles human african trypanosomiasis div >< p clinically relevant species novel therapeutics effective urgently required pan trypanosoma brucei </ species culture systems lipidomic profiles human health african trypanosomes permits effective parasites synthesise lipid biology brucei </ vitro </ congolense </ untargeted lc typically cultured thereby removing supplemented culture species therapies species revealed species chemotherapeutics significant differences severely hindered saharan africa relatively absent pufas ). profound impacts primary cause pathogen interactions observations indicate metabolic distinctions <p>Biologically relevant metabolites with significant variation in abundance between FBS and GS. Log₂ fold-change (FC) analysis (GS/FBS) is summarised alongside their associated P-values (<i>t</i>-test) and false discovery rate (FDR)-adjusted P-values. Positive values indicate higher abundance in GS, negative values indicate higher abundance in FBS. The full dataset is available in the supplementary results (<a href="http://www.plosntds.org/article/info:doi/10.1371/journal.pntd.0014771#pntd.0014771.s005" target="_blank">S1 Table</a>).</p> 2026-09-24T18:01:59Z Dataset Dataset 10.1371/journal.pntd.0014771.t001 https://figshare.com/articles/dataset/_p_Biologically_relevant_metabolites_with_significant_variation_in_abundance_between_FBS_and_GS_Log_sub_2_sub_fold-change_FC_analysis_GS_FBS_is_summarised_alongside_their_associated_P-values_i_t_i_-test_and_false_discovery_rate_FDR_-adjuste/33989149 CC BY 4.0