2026-10-10T03:45:42Z https://api.figshare.com/v2/oai

oai:figshare.com:article/33987642 2026-09-24T17:28:39Z category_1 category_4 category_13 category_21 category_873 category_734 category_132 portal_5 item_type_3 month_year_09_2026

<p>Glycan biosynthetic pathway steps and reachability metrics. Steps within each pathway are connected by AND (min) logic; isozyme groups use OR=mean. Required donors refer to Table 2. 22 glycan pathway metrics plus PAPS donor supply as a standalone metric (23 total; see S4 Table for a complete listing with pathway family, step count, gene count, and primary/composite classification). SHH-like differs from WNT-like by requiring 3-O sulfation. Display names (Metric column) are used throughout the main text; corresponding code variable names are listed in S4 Table.</p> Yusuke Matsui (2047393) Biophysics Biochemistry Genetics Biotechnology Chemical Sciences not elsewhere classified Biological Sciences not elsewhere classified Infectious Diseases losing quantitative information glycan biosynthesis requires div >< p knockout permutation null transcriptomics </ p glycan reachability analysis q </ transport machinery transcriptomic potential transcriptomic coherence sugar synthesis strict minimum step metrics slex pathway seq source selection favored response transcripts readouts share produce continuous nested leave modifying enzymes minimum aggregation limiting step integrates expression gtex associations generating rank explicit expression evaluated across enzymatic activity coordinated expression comparable scores based z aware framework absence calls 19 multi <p>Glycan biosynthetic pathway steps and reachability metrics. Steps within each pathway are connected by AND (min) logic; isozyme groups use OR=mean. Required donors refer to <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1014655#pcbi.1014655.t002" target="_blank">Table 2</a>. 22 glycan pathway metrics plus PAPS donor supply as a standalone metric (23 total; see <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1014655#pcbi.1014655.s015" target="_blank">S4 Table</a> for a complete listing with pathway family, step count, gene count, and primary/composite classification). SHH-like differs from WNT-like by requiring 3-O sulfation. Display names (Metric column) are used throughout the main text; corresponding code variable names are listed in <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1014655#pcbi.1014655.s015" target="_blank">S4 Table</a>.</p> 2026-09-24T17:28:09Z Dataset Dataset 10.1371/journal.pcbi.1014655.t001 https://figshare.com/articles/dataset/_p_Glycan_biosynthetic_pathway_steps_and_reachability_metrics_Steps_within_each_pathway_are_connected_by_AND_min_logic_isozyme_groups_use_OR_mean_Required_donors_refer_to_Table_2_22_glycan_pathway_metrics_plus_PAPS_donor_supply_as_a_standal/33987642 CC BY 4.0