2026-10-12T19:30:26Z
https://api.figshare.com/v2/oai
oai:figshare.com:article/33986797
2026-10-09T18:04:19Z
category_4
category_7
category_19
category_21
category_272
category_873
category_45
category_734
category_61
portal_63
item_type_3
month_year_10_2026
Matrix-Resolved Profiling of the Prenatal Chemical
Exposome Reveals Selective Placental Retention and Fetal Transfer
Montse Marquès (17350326)
Ruben Gil-Solsona (11687132)
Ana González-Ruiz (24797545)
Esteban Restrepo-Montes (17350332)
Ana Megía (25104745)
Monica Ballesteros (25104748)
José L. Domingo (1952986)
Ana Navas-Acien (27358)
Gary W. Miller (50264)
Adrian Covaci (508263)
Pablo Gago-Ferrero (1506517)
Biochemistry
Medicine
Pharmacology
Biotechnology
Environmental Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
Sociology
Biological Sciences not elsewhere classified
Developmental Biology
resolution mass spectrometry
primary physicochemical determinant
prenatal chemical exposure
increase disease vulnerability
including organophosphate esters
chemical landscape across
based analysis across
wide association studies
umbilical cord serum
profiled 659 chemicals
personal care products
including food additives
multiple emerging contaminants
matrix exposome profiling
using wide
transformation products
resolved profiling
maternal serum
industrial chemicals
contaminants
transplacental transfer
transplacental passage
specific distribution
spain ),
selected biomarkers
scalable framework
related compounds
related biomarkers
pregnancy cohorts
placental tissue
placental retention
passive diffusion
maternal urine
insulin cohort
infant dyads
human development
flame retardants
first time
findings highlight
fetal transfer
23 mother
Chemical exposure during human development, especially in utero,
can disrupt many biological processes and increase disease vulnerability.
Assessing the chemical landscape across the maternal–fetal
interface is challenging. Here we address this challenge by conducting
an exposome-based analysis across a suite of integrated maternal–fetal
biological compartments: maternal urine, maternal serum, placental
tissue, and umbilical cord serum. Using wide-scope liquid chromatography–high-resolution
mass spectrometry (LC-HRMS) in 23 mother-infant dyads from the INSULIN
cohort (Spain), we profiled 659 chemicals and transformation products,
enabling a comprehensive characterization of prenatal chemical exposure
and its compartment-specific distribution. We identified 76 unique
compounds, including food additives, personal care products, pharmaceuticals,
plasticizers, pesticides, flame retardants, industrial chemicals,
and tobacco-related biomarkers. Matrix-resolved profiling revealed
distinct compartmentalization patterns, with lipophilicity (logP)
emerging as the primary physicochemical determinant of placental retention
and transplacental transfer, while active transport mechanisms governed
the fetal transfer of selected compounds despite properties inconsistent
with passive diffusion. We report, for the first time, the transplacental
passage of multiple emerging contaminants, including organophosphate
esters, food-related compounds and personal care product ingredients.
In contrast, several other contaminantssuch as selected biomarkers
of plastics, smoke, and personal care productsshowed no evidence
of transplacental transfer. These findings highlight the value of
comprehensive, multi-matrix exposome profiling for assessing prenatal
chemical exposures and provide a scalable framework for exposome-wide
association studies in pregnancy cohorts and beyond.
2026-10-06T00:00:00Z
Dataset
Dataset
10.1021/acs.est.6c02272.s001
https://figshare.com/articles/dataset/Matrix-Resolved_Profiling_of_the_Prenatal_Chemical_Exposome_Reveals_Selective_Placental_Retention_and_Fetal_Transfer/33986797
CC BY-NC 4.0