2026-10-14T10:21:24Z https://api.figshare.com/v2/oai

oai:figshare.com:article/33985924 2026-09-24T13:55:07Z category_7 portal_147 item_type_3 month_year_09_2026

Supplementary Material for: Efficacy and Safety of Yiqi Tongqiao Pill for Allergic Rhinitis With Lung–Spleen Qi Deficiency: A Multicenter Randomized Double-Blind Phase III Trial figshare admin karger (2628495) Zhang Y. (2828780) Liu J. (3215370) Qiao F. (25104262) Chen X. (2888087) Zhu Z. (3610574) Tao B. (17425752) Zheng Z. (4158406) Liu D. (3800659) Medicine Medicine OBJECTIVE: To evaluate the clinical efficacy and safety of Yiqi Tongqiao Pill (YQTP) in treating allergic rhinitis (AR) with a Traditional Chinese Medicine (TCM) pattern of Lung-Spleen Qi Deficiency. METHODS: A multicenter, randomized, double-blind, parallel-controlled, phase III clinical trial was conducted. A total of 480 patients with allergic rhinitis were randomly assigned in a 3:1 ratio to a treatment group (oral YQTP, n=360) and a control group (oral low-dose mimic agent, n=119) for a 2-week course. The primary efficacy endpoint was the change from baseline in the Total Nasal Symptom Score (TNSS) after 2 weeks of treatment. RESULTS: The Full Analysis Set (FAS) included 479 patients. After 2 weeks of treatment, the reduction in TNSS score in the treatment group (5.79±2.23) was significantly greater than that in the control group (0.84±1.82) (P<0.0001). The treatment group also demonstrated significant superiority over the control group in terms of overall response rate (92.78% vs 10.92%), improvement in TCM syndrome score, quality of life, and speed of symptom relief (all P<0.0001). There was no statistically significant difference in the incidence of adverse events between the two groups, indicating a good safety profile. CONCLUSION: YQTP significantly improved nasal symptoms and quality of life over 2 weeks in patients with SAR with the TCM pattern of lung–spleen qi deficiency, with a safety profile comparable to the mimic control. Trial registration: Chinese Clinical Trial Registry (ChiCTR-TRC-13003137); http://www.chictr.org.cn 2026-09-24T13:55:07Z Dataset Dataset 10.6084/m9.figshare.33985924.v1 https://figshare.com/articles/dataset/Supplementary_Material_for_Efficacy_and_Safety_of_Yiqi_Tongqiao_Pill_for_Allergic_Rhinitis_With_Lung_Spleen_Qi_Deficiency_A_Multicenter_Randomized_Double-Blind_Phase_III_Trial/33985924 CC BY 4.0