2026-10-12T21:18:29Z https://api.figshare.com/v2/oai

oai:figshare.com:article/33985906 2026-09-24T13:53:06Z category_696 portal_316 item_type_3 month_year_09_2026

Supplementary file 1_Treg dysregulation in the oxidative lung milieu: an emerging mechanistic link in interstitial lung disease associated with systemic autoimmune rheumatic diseases.docx Yanan Li (94033) Jinghua Wang (101820) Hongsheng Sun (2162863) Min Fu (1322472) Genetic Immunology immune imbalance interstitial lung disease oxidative stress regulatory T cell systemic autoimmune rheumatic disease <p>Systemic autoimmune rheumatic disease-associated interstitial lung disease (SARD-ILD) is a fatal complication, in which the progression of pulmonary fibrosis has been closely linked to immune microenvironment imbalance and oxidative stress. Regulatory T cells (Tregs), as a central component of immune tolerance, play a crucial role in suppressing excessive inflammation. Current evidence suggests that oxidative stress may contribute to Treg dysregulation through several interrelated mechanisms, including redox-sensitive regulation of Foxp3 expression and stability, disruption of IL-2 signaling, and remodeling of the inflammatory microenvironment. However, the majority of the mechanistic evidence is derived from experimental models or related autoimmune and inflammatory conditions, with limited direct validation in patients with SARD-ILD. These proposed interactions may contribute to a self-reinforcing cycle of oxidative stress and Treg dysregulation, potentially promoting effector T-cell activation, fibroblast proliferation, and imbalanced inflammation and repair, thereby contributing to pulmonary fibrotic remodeling. This review integrates current evidence on the potential links among oxidative stress, Treg dysregulation, and pulmonary fibrosis in SARD-ILD, and proposes an emerging mechanistic framework to guide further investigation into their possible interactions and therapeutic implications.</p> 2026-09-24T13:53:06Z Dataset Dataset 10.3389/fimmu.2026.1882853.s001 https://figshare.com/articles/dataset/Supplementary_file_1_Treg_dysregulation_in_the_oxidative_lung_milieu_an_emerging_mechanistic_link_in_interstitial_lung_disease_associated_with_systemic_autoimmune_rheumatic_diseases_docx/33985906 CC BY 4.0