2026-10-14T09:01:03Z https://api.figshare.com/v2/oai

oai:figshare.com:article/33985552 2026-09-24T13:15:26Z category_24634 category_24193 item_type_3 month_year_09_2026

Source data underlying Figures 1–4: Persistent CCL3 expression sustains neutrophil recruitment and contributes to delayed wound healing in advanced age Yonlada Nawilaijaroen (22275886) Immunology not elsewhere classified Genomics and transcriptomics CCL3 inflammatory cytokines Inflammation Wound healing Age impaired healing <p dir="ltr">This Excel workbook contains the numerical source data used to generate the graphs and quantitative analyses presented in Figures 1–4 of the associated study investigating age-associated differences in cutaneous wound healing and inflammatory responses.</p><p dir="ltr">Data are organised into individual worksheets according to figure and include measurements from young and aged mice. The workbook contains:</p><ul><li><b>Figure 1:</b> wound area measurements, scab presence, and epithelial gap measurements over the course of wound healing.</li><li><b>Figure 2:</b> quantification of wound-bed neutrophils and macrophages, together with analyses of neutrophil proximity to macrophages and the perivascular niche.</li><li><b>Figure 3:</b> Gene Ontology (GO) enrichment results, differential gene-expression data, and expression measurements for <b>Ccl3, Cxcl2, and Cxcl3</b> in young and age-impaired wounds. Separate worksheets (<b>Figure 3D_young</b> and <b>Figure 3D_old</b>) contain gene-level log fold-change and adjusted P-value data used for the differential-expression analysis.</li><li><b>Figure 4:</b> quantification and cellular composition of CCL3⁺ cells, wound-healing measurements following CCL3-neutralising antibody treatment, wound-width measurements, and Ly6G⁺ neutrophil quantification.</li></ul><p dir="ltr">Values are provided at the level used for statistical analysis and/or generation of the corresponding graphs in the manuscript. Where applicable, individual columns or rows represent measurements from individual biological samples or experimental groups.</p><p dir="ltr">Abbreviations: DPI/dpw, days post-injury/days post-wounding; GO, Gene Ontology; DEG, differentially expressed gene.</p> 2026-09-24T13:15:26Z Dataset Dataset 10.6084/m9.figshare.33985552.v1 https://figshare.com/articles/dataset/Source_data_underlying_Figures_1_4_Persistent_CCL3_expression_sustains_neutrophil_recruitment_and_contributes_to_delayed_wound_healing_in_advanced_age/33985552 CC BY 4.0