2026-10-13T04:09:26Z https://api.figshare.com/v2/oai

oai:figshare.com:article/33981316 2026-09-24T10:29:14Z category_7 portal_147 item_type_3 month_year_09_2026

Supplemental Material for: Toxic epidermal necrolysis secondary to nodal T-follicular helper cell lymphoma, not otherwise specified: a case report figshare admin karger (2628495) Rie HYOBU (25103423) Kenichiro MAE (25103427) Aya TAKAHASHI (25103429) Tatsuo MAEDA (25103436) Kazutoshi HARADA (25103439) Medicine Medicine <p dir="ltr">Introduction: Nodal T-follicular helper cell lymphoma (nTFHL) is a rare subtype of peripheral T-cell lymphoma in which cutaneous manifestations occur in approximately half the patients. Case Presentation: We report herein a case of toxic epidermal necrolysis (TEN) in a 62-year-old, male, Japanese patient with nTFHL, not otherwise specified. The patient experienced the development of rapidly progressive, erythematous plaques with blistering and erosion involving more than 30% of the body surface area. Histopathological examination of the skin revealed total epidermal necrosis without lymphoma cell infiltration while immunohistochemical analysis demonstrated depletion of FOXP3-positive cells. The TEN was successfully treated with systemic corticosteroid therapy, plasma exchange, and intravenous immunoglobulin. Although EBER-positive B cells in lymph nodes and EBV DNAemia were detected, their contribution to the TEN remains unclear. Conclusion: This case expands the spectrum of severe, cutaneous manifestations associated with nTFHL and suggests that a reduction of regulatory T cells, previously reported in lymph nodes, may also occur locally in the skin and contribute to the development of cutaneous manifestations.</p> 2026-09-24T10:29:14Z Dataset Dataset 10.6084/m9.figshare.33981316.v1 https://figshare.com/articles/dataset/Supplemental_Material_for_Toxic_epidermal_necrolysis_secondary_to_nodal_T-follicular_helper_cell_lymphoma_not_otherwise_specified_a_case_report/33981316 CC BY 4.0