2026-10-14T10:58:29Z https://api.figshare.com/v2/oai

oai:figshare.com:article/33981286 2026-09-24T10:22:59Z category_7 portal_147 item_type_3 month_year_09_2026

Supplemental Material for: Temporal trends in biopsy-proven kidney diseases: an analysis of 14,447 cases from Northern China, 2012–2023 figshare admin karger (2628495) Ai-bo Qin (17081045) Zeng-xin Chi (25103398) Su-xia Wang (823505) Ming-hui Zhao (3926921) Fu-de Zhou (8176911) Medicine Medicine <p dir="ltr">Introduction: The spectrum of kidney diseases exhibits dynamic shifts driven by demographic transitions, diagnostic progress, and environmental alterations. This study aimed to delineate temporal changes in the pathological spectrum of biopsy-proven native kidney diseases in Northern China over a 12-year interval.</p><p dir="ltr">Methods: This retrospective study included all patients who underwent native kidney biopsy and received a definitive histopathological diagnosis at Peking University First Hospital between 2012 and 2023.</p><p dir="ltr">Results: A total of 14,447 cases were analyzed. Primary glomerulonephritis (PGN), secondary glomerulonephritis (SGN), tubulointerstitial disease (TIN), hereditary renal diseases, and other pathologies constituted 64.6%, 28.7%, 4.4%, 1.8%, and 0.4%, respectively. The proportion of PGN decreased significantly (P < 0.001), while SGN increased (P < 0.001). IgA nephropathy (IgAN) was the predominant PGN subtype (46.1%). Membranous nephropathy (MN) showed a nonsignificant upward tendency before 2017 and declined significantly thereafter. Among SGN, lupus nephritis (LN) decreased significantly (P < 0.001), whereas diabetic nephropathy (DN) more than doubled and overtook LN as the leading subtype after 2018. Hypertensive nephropathy (HT) nearly tripled, obesity-related glomerulopathy (ORG) more than doubled, and monoclonal immunoglobulin-related renal diseases (MIg-RD) also increased significantly (P = 0.003).</p><p dir="ltr">Conclusion: PGN remained the most common pathological category, with IgAN and MN as the major subtypes. IgAN exhibited an upward trend, whereas MN showed a nonsignificant upward tendency before 2017 and declined significantly thereafter. LN decreased significantly. In contrast, DN, HT, ORG, and MIg-RD all increased significantly. DN has overtaken LN as the leading SGN subtype since 2018, reflecting an evolving pattern toward metabolic-related kidney injury.</p> 2026-09-24T10:22:59Z Dataset Dataset 10.6084/m9.figshare.33981286.v1 https://figshare.com/articles/dataset/Supplemental_Material_for_Temporal_trends_in_biopsy-proven_kidney_diseases_an_analysis_of_14_447_cases_from_Northern_China_2012_2023/33981286 CC BY 4.0