2026-10-14T06:30:47Z https://api.figshare.com/v2/oai

oai:figshare.com:article/33980204 2026-09-26T04:13:42Z category_7 category_12 category_13 category_16 category_46 portal_87 item_type_3 month_year_09_2026

Allergic rhinitis duration and small-airway dysfunction in adolescents without asthma: a cross-sectional impulse oscillometry study Gulce Polat (25102472) Cihangir Sahin (25102475) Zeynep Gulec Koksal (25102478) Adnan Mercan (20149810) Simge Atar Bese (20149807) Gulten Tuncerler (24514406) Nur Torer (25102481) Ozge Cevik (702327) Imran Kurt Omurlu (25102484) Selime Ozen Boluk (25102487) Pinar Uysal (20795322) Duygu Erge (20149813) Medicine Cell Biology Genetics Physiology Immunology Allergic rhinitis impulse oscillometry small-airway dysfunction endocan adolescents disease duration <p>Allergic rhinitis (AR) is a mucosal inflammatory disease increasingly viewed within a united-airway framework, yet whether lower-airway function deteriorates as AR persists in adolescents without asthma remains unclear. We used impulse oscillometry (IOS) to examine the relationship between AR duration and small-airway function, and examined serum endocan (endothelial cell-specific molecule-1, ESM-1), whose relationship to airway function in AR is unknown, as a candidate systemic biomarker.</p> <p>Forty treatment-naïve, aeroallergen-sensitized adolescents (12–17 years) with AR and 37 non-atopic controls of comparable age and sex underwent IOS, serum endocan measurement (ELISA, enzyme-linked immunosorbent assay), specific immunoglobulin E (IgE) testing, and skin prick testing. Symptoms were scored on a visual analog scale, and core IOS indices were expressed as age- and sex-adjusted <i>z</i>-scores.</p> <p>No IOS parameter differed between patients and controls. However, longer AR duration was associated with higher total-airway resistance (zR5 <i>r</i> = 0.323, <i>p</i> = 0.042) and lower reactance (zX5 <i>r</i> = −0.502, <i>p</i> < 0.001); specific IgE also increased with age, duration, and severity. Serum endocan levels were similar in patients and controls (median 200.8 vs. 218.8 ng/mL; <i>p</i> = 0.517) and, within the AR group, did not correlate with severity, persistence, or IOS parameters.</p> <p>Greater oscillometric small-airway dysfunction was associated with longer AR duration, supporting the use of IOS to assess lower-airway function in adolescents with long-standing AR. Serum endocan did not distinguish patients from controls; because paired airway sampling was not performed, whether any endocan signal in AR is confined to the airway mucosa remains speculative.</p> 2026-09-26T04:13:42Z Dataset Dataset 10.6084/m9.figshare.33980204.v2 https://figshare.com/articles/dataset/Allergic_Rhinitis_Duration_and_Small-Airway_Dysfunction_in_Adolescents_Without_Asthma_A_Cross-Sectional_Impulse_Oscillometry_Study/33980204 CC BY 4.0