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oai:figshare.com:article/33979921 2026-09-24T05:33:08Z category_15 portal_316 item_type_3 month_year_09_2026

Table 1_Low-density lipoprotein cholesterol modulates amyloid-related entorhinal vulnerability and episodic memory performance in older adults.docx Minh Le Tran (16490953) Kahye Kim (12716858) Jaeuk U. Kim (12395383) Yu Yong Choi (9233111) JunHyeong Do (25102234) Kun Ho Lee (7465397) Ji-Woo Seok (5784686) Neuroscience Alzheimer’s disease amyloid-beta entorhinal cortex episodic memory low-density lipoprotein cholesterol moderated mediation Introduction<p>Cerebral amyloid-beta (Aβ) burden does not fully explain variation in Alzheimer’s disease (AD)-related brain structure and episodic memory. We examined whether circulating low-density lipoprotein cholesterol (LDL-C) modifies the cross-sectional statistical association between Aβ burden, the entorhinal cortex (EC) thickness and episodic memory performance.</p>Methods<p>Cross-sectional data from 1,253 individuals in the Gwangju Alzheimer’s Disease and Related Dementias cohort (798 cognitively normal, 425 mild cognitive impairment, 30 AD dementia) were analyzed. Primary conditional-process models were adjusted for age, sex, education, body mass index, and HbA1c; clinical diagnosis was examined in sensitivity analyses. HC3 heteroskedasticity-consistent inference was used for the focal interaction, and indirect associations were estimated using 10,000 bootstrap resamples.</p>Results<p>Greater Aβ burden was associated with lower EC thickness (β = −0.0863, p = 0.0012), and EC thickness was positively associated with episodic memory (β = 0.3809, p < 0.001). The unconditional indirect statistical association was supported (β = −0.0329, 95% bias-corrected bootstrap CI [−0.0647, −0.0072]). LDL-C modified the Aβ–EC association (β = −0.0937, HC3 SE = 0.0332, 95% CI [−0.1589, −0.0285], p = 0.0049), although the incremental explanatory magnitude was small (ΔR² = 0.0082). The conditional Aβ–EC association was unsupported at approximately 66 mg/dL LDL-C (β = 0.0263, p = 0.583), not statistically supported at approximately 100 mg/dL (β = −0.0639, p = 0.060), and negative at 138 mg/dL (β = −0.1648, p < 0.001). The index of moderated indirect association was supported (β = −0.0357, 95% bias-corrected bootstrap CI [−0.0637, −0.0119]); conditional indirect associations were most clearly supported at higher LDL-C levels. A similar interaction was observed for non-HDL cholesterol, suggesting that the pattern may reflect a broader atherogenic lipid context.</p>Conclusion<p>Circulating LDL-C was associated with modest heterogeneity in the cross-sectional Aβ–EC relationship, with more clearly negative conditional associations observed at higher LDL-C levels. Longitudinal studies are needed to determine the temporal and clinical relevance of these findings.</p> 2026-09-24T05:33:08Z Dataset Dataset 10.3389/fnagi.2026.1933036.s001 https://figshare.com/articles/dataset/Table_1_Low-density_lipoprotein_cholesterol_modulates_amyloid-related_entorhinal_vulnerability_and_episodic_memory_performance_in_older_adults_docx/33979921 CC BY 4.0