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oai:figshare.com:article/33979669 2026-09-24T04:37:52Z category_658 portal_316 item_type_3 month_year_09_2026

Supplementary file 1_Cross-sectional associations and incremental discrimination of inflammatory and lipid-derived indices for prevalent coronary heart disease in type 2 diabetes.docx Changlin Xie (17698973) Lingjiao Meng (11905665) Yifan Wang (380120) Yilin Wang (490921) Haijiao Shi (12968108) Cell Metabolism coronary heart disease cross-sectional association inflammatory indices internal validation systemic immune-inflammation index type 2 diabetes mellitus Background<p>Routine blood-count and lipid-derived indices may be associated with coronary heart disease (CHD) in type 2 diabetes mellitus (T2DM), but comparative evidence within one cohort is limited.</p>Methods<p>This cross-sectional study included 3,964 adults with T2DM. Six inflammatory and three lipid-derived indices were examined using quartile-based and standardized continuous logistic regression. Domain-specific covariate sets avoided adjustment for constituent lipids. Dose–response, subgroup, and temporal sensitivity analyses were performed. Incremental discrimination was assessed against a common clinical base model with bootstrap optimism correction. Calibration and decision curves were based on cross-validated estimated probabilities; high-sensitivity C-reactive protein was a benchmark.</p>Results<p>CHD was present in 1,350 participants (34.1%). Median SII was 649 × 10⁹/L in participants with CHD and 522 × 10⁹/L in those without CHD (P < 0.001). The adjusted OR for SII was 2.37 (95% CI, 1.91–2.93) for Q4 versus Q1 and 1.46 (95% CI, 1.36–1.58) per 1-SD increase. The association was nonlinear (P for nonlinearity < 0.001), with no interaction by sex, age, BMI, or hypertension. The optimism-corrected AUC increased from 0.729 to 0.744 after adding SII (ΔAUC = 0.015, P < 0.001); corrected AUCs were 0.744 for PIV and 0.745 for SIRI. Paired comparisons showed no statistically significant difference between the SII-augmented model and either the PIV-augmented model (P = 0.964) or the SIRI-augmented model (P = 0.717). The SII model showed a cross-validated AUC of 0.742, Brier score of 0.188, ICI of 0.017, and calibration slope of 0.963.</p>Conclusion<p>Several indices were associated with prevalent CHD, without consistent evidence that SII was superior.</p> 2026-09-24T04:37:52Z Dataset Dataset 10.3389/fendo.2026.1961170.s001 https://figshare.com/articles/dataset/Supplementary_file_1_Cross-sectional_associations_and_incremental_discrimination_of_inflammatory_and_lipid-derived_indices_for_prevalent_coronary_heart_disease_in_type_2_diabetes_docx/33979669 CC BY 4.0