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oai:figshare.com:article/33976396 2026-09-23T17:40:36Z category_4 category_7 category_12 category_21 category_46 category_64 category_106 category_128 category_132 category_135 portal_5 item_type_3 month_year_09_2026

<p>Indications of Liver Resection.</p> Mohammad Saydul Aman (25099333) Md. Shawkat Ali (25099336) Bishow Raj Khadka (25099339) Bineet Kumar Yadav (25099342) Bidhan Chandra Das (25099345) Md Foyjul Islam (20421996) Biochemistry Medicine Cell Biology Biotechnology Immunology Cancer Science Policy Hematology Infectious Diseases Computational Biology wide confidence interval grade &# 8805 following liver resection exploratory multivariable analysis clavien &# 8211 broad composite endpoint 655 &# 8211 648 &# 8211 614 &# 8211 53 &# 181 44 &# 8211 240 &# 181 23 &# 181 10 &# 181 022 ); however seventh postoperative days two groups based early marker associated 927 ), 0 postoperative complications early predictors wbc ), 920 ), youden index timely intervention small number significantly higher severe morbidity serum procalcitonin serum pct requires validation reactive protein prespecified covariates pod ). limited settings july 2022 iii complications findings suggest clinical utility august 2021 achieved 86 71 vs 69 vs 48 vs <div><p>Postoperative complications (POC) following liver resection (LR) can significantly affect patient outcomes, and early predictors are crucial for timely intervention, particularly in resource-limited settings such as Bangladesh. In this prospective observational study conducted from August 2021 to July 2022, 42 patients undergoing LR were enrolled and divided into two groups based on the presence (n = 22) or absence (n = 20) of POC. Serum procalcitonin (PCT), white blood cell count (WBC), and C-reactive protein (CRP) were measured on the first, third, and seventh postoperative days (POD). Median serum PCT levels were significantly higher in patients with POC on all PODs (POD1: 1.71 vs. 0.53 µg/L, p = 0.001; POD3: 0.69 vs. 0.23 µg/L, p = 0.001; POD7: 0.48 vs. 0.10 µg/L, p = 0.003), whereas WBC and CRP did not differ between groups. The area under the receiver operating characteristic curve (AUC) for serum PCT was 0.798 (95% CI: 0.655–0.927), 0.797 (95% CI: 0.648–0.920), and 0.769 (95% CI: 0.614–0.898) on POD1, POD3, and POD7, respectively, indicating that POD1 serum PCT showed moderate discriminatory ability for the broad composite endpoint. Using the Youden index, the optimal POD1 serum PCT cutoff value was identified as 1.240 µg/L, which achieved 86.4% sensitivity and 70.0% specificity. In exploratory multivariable analysis, higher POD1 serum PCT was associated with postoperative complications after adjustment for prespecified covariates (adjusted OR: 12.30; 95% CI: 1.44–104.89; p = 0.022); however, the wide confidence interval and small number of events warrant cautious interpretation. Sensitivity analyses showed reduced discrimination for Clavien–Dindo grade ≥II (AUC: 0.650) and grade ≥III complications (AUC: 0.581), indicating limited discriminatory ability for severe morbidity in this dataset. These findings suggest that POD1 PCT may support early postoperative risk stratification, but its clinical utility, particularly for severe morbidity, requires validation in larger studies.</p></div> 2026-09-23T17:40:30Z Dataset Dataset 10.1371/journal.pone.0338171.t002 https://figshare.com/articles/dataset/_p_Indications_of_Liver_Resection_p_/33976396 CC BY 4.0