2026-10-14T13:36:14Z https://api.figshare.com/v2/oai

oai:figshare.com:article/33974446 2026-09-23T17:02:28Z category_24199 item_type_3 month_year_09_2026

Loss of Bone Marrow β1/β2-Adrenergic Receptors Reprograms Host-Microbiota Interactions and Reduces Visceral Adiposity During Short-term High-fat Diet Feeding- Supplementary Table 1 Adriana Alviter Plata (25098772) Sequence analysis microbiota bacteroides abundance lipids FAT/CD36 <p dir="ltr">The gut ecosystem is shaped by multiple factors, and the immune system is a major determinant of gut microbiota composition in health and disease. The sympathetic nervous system (SNS), in turn, regulates immune function through beta-adrenergic receptor (ADRB) 1 and 2 signaling. Our previous study showed that mice transplanted with whole bone marrow from ADRB1/2 knockout donors (KD mice) exhibited mild immunosuppression and shifts in gut microbiota composition. Because these systems are each implicated in diet-induced obesity, we examined how KD mice respond to a two-week high-fat diet (HFD) challenge. KD mice had lower visceral fat mass than WT controls on HFD, whereas the between-group difference in weight gain did not reach statistical significance. These findings were accompanied by Bacteroidetes enrichment, altered fecal and serum lipid profiles, and lower colonic expression of the fatty acid transporter FAT/CD36. Fecal lipid profiles showed a lower relative frequency of triglycerides (TAGs) and a higher relative frequency of diglycerides (DAGs) in KD mice. Whole microbiome cultures from control-fed KD donors also showed a lower TAG-to-DAG ratio after incubation with HFD lipid extract. Together, these findings associate loss of bone marrow ADRB1/2 signaling with altered microbial composition, intestinal lipid handling, and reduced visceral adiposity during short-term HFD feeding. They support further investigation of the contribution of host immunity and microbial lipid metabolism to these early metabolic responses.</p> 2026-09-23T17:02:28Z Dataset Dataset 10.6084/m9.figshare.33974446.v1 https://figshare.com/articles/dataset/Loss_of_Bone_Marrow_1_2-Adrenergic_Receptors_Reprograms_Host-Microbiota_Interactions_and_Reduces_Visceral_Adiposity_During_Short-term_High-fat_Diet_Feeding-_Supplementary_Table_1/33974446 CC BY 4.0