2026-10-13T05:14:31Z
https://api.figshare.com/v2/oai
oai:figshare.com:article/33974378
2026-09-23T16:04:47Z
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A Novel Transcription
Factor FgHOY1 Regulates OS1
Transcription to Mediate Fludioxonil Resistance in Fusarium graminearum
Zikuo Li (22139655)
Haoxue Xia (11728742)
Yaru He (17836610)
Xuheng Gao (14481254)
Songbai Zhang (183187)
Wende Liu (232617)
Guangfei Tang (4785972)
Microbiology
Genetics
Biotechnology
Immunology
Biological Sciences not elsewhere classified
Developmental Biology
Infectious Diseases
Plant Biology
Computational Biology
threaten food safety
regulates hog1 phosphorylation
mediated regulatory pathway
disease green prevention
rational fungicide application
fghoy1 directly binds
transcription factor fghoy1
mediate fludioxonil resistance
modulate transcription
exploring fungicide
resistance networks
fludioxonil resistance
fghoy1 </
theoretical basis
study elucidates
study clarifies
stalk rot
pathogen produces
os1 promoter
molecular mechanism
mainly caused
fusarium graminearum
contaminate maize
Maize ear rot and stalk rot are mainly caused by Fusarium graminearum, which severely reduces maize
yield. This pathogen produces DON mycotoxin to contaminate maize and
threaten food safety. Fludioxonil exhibits high control efficacy against
this fungus, while its regulatory mechanism remains poorly understood.
This study elucidates the molecular mechanism of transcription factor
FgHOY1 in response to fludioxonil. FgHOY1 regulates hyphal growth,
conidiation, pathogenicity and DON biosynthesis, and Δ<i>FgHOY1</i> strain shows markedly enhanced fludioxonil resistance.
Fludioxonil treatment significantly downregulates the expression of <i>FgHOY1</i>. Meanwhile, FgHOY1 directly binds to the OS1 promoter
to modulate transcription and regulates Hog1 phosphorylation. This
study clarifies the FgHOY1-mediated regulatory pathway of fludioxonil
resistance, providing a theoretical basis for exploring fungicide-resistance
networks, disease green prevention and rational fungicide application.
2026-09-23T00:00:00Z
Dataset
Dataset
10.1021/acs.jafc.6c06851.s002
https://figshare.com/articles/dataset/A_Novel_Transcription_Factor_FgHOY1_Regulates_OS1_Transcription_to_Mediate_Fludioxonil_Resistance_in_Fusarium_graminearum/33974378
CC BY-NC 4.0